The neuroprotective effect of isatin in the rotenone-induced model of parkinonism in rats: the study of delayed effects.

Q3 Biochemistry, Genetics and Molecular Biology Biomeditsinskaya khimiya Pub Date : 2024-08-01 DOI:10.18097/PBMC20247004231

O A Buneeva, I G Kapitsa, L Sh Kazieva, N E Vavilov, V G Zgoda, A E Medvedev

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Abstract

Parkinsonism in rats induced by the pesticide rotenone is one of the most adequate models of Parkinson's disease (PD). Isatin (indole-2,3-dione) is an endogenous regulator found in mammals and humans and exhibiting a wide range of biological activities mediated by numerous isatin-binding proteins, including those associated with neurodegenerative pathology. A course of rotenone administration to rats caused behavioral impairments and changes in the profile and relative content of isatin-binding proteins in the brain. In this study, we have investigated the delayed neuroprotective effect of isatin (5 days after completion of the course of rotenone administration) on behavioral reactions and the relative content of isatin-binding proteins in the brain of rats with rotenone-induced experimental parkinsonism. Although during this period the rats retained locomotor dysfunction, the proteomic analysis data (profile of isatin-binding proteins in the brain and changes in their relative content) differed from the results obtained immediately after completion of the course of rotenone administration. Moreover, all isatin-binding proteins with altered relative content changed during this period are associated to varying degrees with neurodegeneration (many with Parkinson's and Alzheimer's diseases).

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伊沙替丁在鱼藤酮诱导的帕金森氏症大鼠模型中的神经保护作用：延迟效应研究。

由杀虫剂鱼藤酮诱发的大鼠帕金森病是帕金森病（PD）最适当的模型之一。异丁烯二酮（吲哚-2,3-二酮）是哺乳动物和人类体内的一种内源性调节剂，由多种异丁烯结合蛋白介导，具有广泛的生物活性，其中包括与神经退行性病理学相关的蛋白。给大鼠服用一个疗程的鱼藤酮会导致行为障碍，并改变大脑中异汀结合蛋白的轮廓和相对含量。在这项研究中，我们研究了伊沙替丁对行为反应和伊沙替丁结合蛋白在鱼藤酮诱导的实验性帕金森病大鼠大脑中相对含量的延迟神经保护作用（在鱼藤酮给药疗程结束后 5 天）。尽管在此期间大鼠仍存在运动功能障碍，但蛋白质组分析数据（大脑中伊沙丁结合蛋白的概况及其相对含量的变化）与服用鱼藤酮疗程结束后立即获得的结果有所不同。此外，在此期间相对含量发生变化的所有异丁烯结合蛋白在不同程度上都与神经变性有关（许多与帕金森氏症和阿尔茨海默氏症有关）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biomeditsinskaya khimiya Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)

CiteScore

1.30

自引率

0.00%

发文量

期刊介绍： The aim of the Russian-language journal "Biomeditsinskaya Khimiya" (Biomedical Chemistry) is to introduce the latest results obtained by scientists from Russia and other Republics of the Former Soviet Union. The Journal will cover all major areas of Biomedical chemistry, including neurochemistry, clinical chemistry, molecular biology of pathological processes, gene therapy, development of new drugs and their biochemical pharmacology, introduction and advertisement of new (biochemical) methods into experimental and clinical medicine etc. The Journal also publish review articles. All issues of journal usually contain invited reviews. Papers written in Russian contain abstract (in English).