Directionality theory and mortality patterns across the primate lineage.

IF 4.4 4区 医学 Q1 GERIATRICS & GERONTOLOGY Biogerontology Pub Date : 2024-11-01 Epub Date: 2024-09-06 DOI:10.1007/s10522-024-10134-6
Lloyd A Demetrius, Anand Sahasranaman, Martin Ziehe
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Abstract

Empirical studies of aging in primates show that local selective forces rather than phylogenetic history determine the exceptional nature of human longevity (Bronikowski et al., Science 331:1325-1328, 2011). This article proposes an evolutionary rationale for this pattern of primate mortality by invoking the parameter, Life-Table Entropy, a measure of the uncertainty in the life span of a randomly chosen newborn. Life-table entropy is positively correlated with maximal life span, that is, the mean life span of a species living under favourable conditions.The logic which underlies the exceptional nature of human longevity derives from the terrestrial life-history of humans - a singularity within the primate lineage; and the concomitant ecological constraints-the hunter-gatherer, agricultural, and industrial modes of subsistence, that have defined human evolutionary history. The effect of these ecological constraints on the evolution of life span is encoded in the Entropic Principle of Longevity: life-table entropy increases in equilibrium species, populations evolving in environments with stable, renewable resources; and decreases in opportunistic species, populations subject to fluctuating resource endowments.The Entropic Principle of Longevity is a derivative of Directionality Theory, an analytic study of the evolutionary process of variation and selection based on Evolutionary Entropy, a statistical measure of the uncertainty in the age of the mother of a randomly chosen newborn. Evolutionary entropy is the organizing concept of The Entropic Principle of Evolution: Evolutionary Entropy increases in equilibrium species and decreases in opportunistic species.

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灵长类的方向性理论和死亡率模式。
对灵长类动物衰老的实证研究表明,决定人类长寿特殊性的是当地的选择性力量而非系统发育历史(Bronikowski 等人,《科学》331:1325-1328,2011 年)。生命表熵是一个衡量随机选择的新生儿寿命不确定性的参数。生命表熵与最大寿命(即在有利条件下生活的物种的平均寿命)呈正相关。人类长寿的特殊性所依据的逻辑源于人类的陆地生活史--灵长类中的一个奇点;以及伴随而来的生态限制--狩猎-采集、农业和工业生存模式,这些限制决定了人类的进化史。这些生态制约因素对寿命进化的影响体现在 "长寿熵原理 "中:平衡物种(在资源稳定、可再生的环境中进化的种群)的生命表熵增加;机会主义物种(受波动性资源禀赋影响的种群)的生命表熵减小。熵长寿原理是方向性理论(Directionality Theory)的衍生理论,该理论是基于进化熵(Evolutionary Entropy)对变异和选择的进化过程进行的分析研究,进化熵是对随机选择的新生儿母亲年龄的不确定性的统计量度。进化熵是进化熵原理的组织概念:进化熵在平衡物种中增加,在机会物种中减少。
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来源期刊
Biogerontology
Biogerontology 医学-老年医学
CiteScore
8.00
自引率
4.40%
发文量
54
审稿时长
>12 weeks
期刊介绍: The journal Biogerontology offers a platform for research which aims primarily at achieving healthy old age accompanied by improved longevity. The focus is on efforts to understand, prevent, cure or minimize age-related impairments. Biogerontology provides a peer-reviewed forum for publishing original research data, new ideas and discussions on modulating the aging process by physical, chemical and biological means, including transgenic and knockout organisms; cell culture systems to develop new approaches and health care products for maintaining or recovering the lost biochemical functions; immunology, autoimmunity and infection in aging; vertebrates, invertebrates, micro-organisms and plants for experimental studies on genetic determinants of aging and longevity; biodemography and theoretical models linking aging and survival kinetics.
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