Unveiling the role of RNA methylation in glioma: Mechanisms, prognostic biomarkers, and therapeutic targets

IF 4.4 2区生物学 Q2 CELL BIOLOGY Cellular signalling Pub Date : 2024-09-03 DOI:10.1016/j.cellsig.2024.111380

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Abstract

Gliomas, the most prevalent malignant brain tumors in the central nervous system, are marked by rapid growth, high recurrence rates, and poor prognosis. Glioblastoma (GBM) stands out as the most aggressive subtype, characterized by significant heterogeneity. The etiology of gliomas remains elusive. RNA modifications, particularly reversible methylation, play a crucial role in regulating transcription and translation throughout the RNA lifecycle. Increasing evidence highlights the prevalence of RNA methylation in primary central nervous system malignancies, underscoring its pivotal role in glioma pathogenesis. This review focuses on recent findings regarding changes in RNA methylation expression and their effects on glioma development and progression, including N6-methyladenosine (m6A), 5-methylcytosine (m5C), N1-methyladenosine (m1A), and N7-methylguanosine (m7G). Given the extensive roles of RNA methylation in gliomas, the potential of RNA methylation-related regulators as prognostic markers and therapeutic targets was also explored, aiming to enhance clinical management and improve patient outcomes.

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揭示 RNA 甲基化在胶质瘤中的作用：机制、预后生物标志物和治疗目标。

胶质瘤是中枢神经系统中最常见的恶性脑肿瘤，具有生长快、复发率高、预后差等特点。胶质母细胞瘤（GBM）是侵袭性最强的亚型，具有显著的异质性。胶质瘤的病因仍然难以捉摸。RNA 修饰，尤其是可逆甲基化，在整个 RNA 生命周期中对转录和翻译起着至关重要的调控作用。越来越多的证据表明，RNA甲基化在原发性中枢神经系统恶性肿瘤中非常普遍，这突出了它在胶质瘤发病机制中的关键作用。本综述将重点讨论有关 RNA 甲基化表达变化及其对胶质瘤发展和进展的影响的最新发现，包括 N6-甲基腺苷（m6A）、5-甲基胞嘧啶（m5C）、N1-甲基腺苷（m1A）和 N7-甲基鸟苷（m7G）。鉴于 RNA 甲基化在胶质瘤中的广泛作用，研究人员还探讨了 RNA 甲基化相关调节因子作为预后标志物和治疗靶点的潜力，旨在加强临床管理和改善患者预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cellular signalling 生物-细胞生物学

CiteScore

8.40

自引率

0.00%

发文量

250

审稿时长

27 days

期刊介绍： Cellular Signalling publishes original research describing fundamental and clinical findings on the mechanisms, actions and structural components of cellular signalling systems in vitro and in vivo. Cellular Signalling aims at full length research papers defining signalling systems ranging from microorganisms to cells, tissues and higher organisms.