Impact of depression on clinical outcomes of peritoneal dialysis: A systematic review and meta-analysis.

IF 1.1 4区 医学 Q3 UROLOGY & NEPHROLOGY Clinical nephrology Pub Date : 2024-09-06 DOI:10.5414/CN111454
Meiling Xu, Wei Zhang
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Abstract

Objective: Depression has become a highly prevalent mental disorder around the globe. With a large number of end-stage renal disease patients taking up peritoneal dialysis (PD), a substantial number of PD patients with concomitant depression are expected to be treated in the future. However, the effects of depression on outcomes of PD are unclear. This review systematically examines the effect of depression on mortality, technique survival, or peritonitis in PD patients.

Materials and methods: Studies comparing outcomes of PD patients with and without depression and published on Google Scholar, Embase, Web of Science, and PubMed till February 5, 2024 were included.

Results: Eleven studies were eligible; 5 studies reported data on mortality. Pooled analysis showed that depression was not a significant predictor of mortality in PD patients (HR: 1.22 95% CI: 0.86, 1.72). Only 2 studies reported analyzable data on technique survival and 3 studies on peritonitis. Meta-analysis found no statistically significant effect of depression on technique survival (OR: 1.28 95% CI: 0.38, 4.35) and peritonitis (OR: 1.89 95% CI: 0.82, 4.33). Qualitative analysis of remaining studies also suggested no effect of depression on patient and technique survival.

Conclusion: Depression may not be an independent predictor of patient and technique survival in PD patients. Data on the risk of peritonitis is conflicting and needs to be investigated further.

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抑郁症对腹膜透析临床结果的影响:系统回顾和荟萃分析。
目的:抑郁症已成为全球高发的精神疾病。随着大量终末期肾病患者接受腹膜透析(PD)治疗,预计未来将有大量伴有抑郁症的腹膜透析患者接受治疗。然而,抑郁症对腹膜透析疗效的影响尚不明确。本综述系统研究了抑郁症对腹膜透析患者死亡率、技术存活率或腹膜炎的影响:纳入截至 2024 年 2 月 5 日在 Google Scholar、Embase、Web of Science 和 PubMed 上发表的比较有抑郁症和无抑郁症的腹腔镜手术患者预后的研究:结果:11项研究符合条件;5项研究报告了死亡率数据。汇总分析表明,抑郁症不是预测帕金森病患者死亡率的重要因素(HR:1.22 95% CI:0.86, 1.72)。只有 2 项研究报告了技术存活率方面的可分析数据,3 项研究报告了腹膜炎方面的可分析数据。Meta 分析发现,抑郁对技术存活率(OR:1.28 95% CI:0.38, 4.35)和腹膜炎(OR:1.89 95% CI:0.82, 4.33)没有统计学意义上的显著影响。对其余研究的定性分析也表明,抑郁症对患者和技术的存活率没有影响:结论:抑郁可能不是腹腔镜手术患者存活率和技术存活率的独立预测因素。有关腹膜炎风险的数据相互矛盾,需要进一步研究。
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来源期刊
Clinical nephrology
Clinical nephrology 医学-泌尿学与肾脏学
CiteScore
2.10
自引率
9.10%
发文量
138
审稿时长
4-8 weeks
期刊介绍: Clinical Nephrology appears monthly and publishes manuscripts containing original material with emphasis on the following topics: prophylaxis, pathophysiology, immunology, diagnosis, therapy, experimental approaches and dialysis and transplantation.
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