Design and evaluation of a drug-in-adhesive patch for the transdermal delivery of ketoprofen.

IF 5.7 3区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL Drug Delivery and Translational Research Pub Date : 2024-09-06 DOI:10.1007/s13346-024-01703-w

Ran Bai, Miaomiao Yang, Xiaoyang Sun, Yanqin Hu, Kaiwen Chen, Xiaoyue Cui, Yinghua Sun, Tianhong Zhang

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Abstract

The purpose of this study was to design a drug-in-adhesive (DIA) patch for transdermal delivery of ketoprofen, using hot-melt pressure-sensitive adhesive as the matrix of the patch. The adhesion properties and skin permeation of the patches were examined, and in vivo pharmacokinetics and tissue distribution of patches were evaluated. The novel ketoprofen patch with high adhesion was prepared by holt-melt method. The effects of different percentages of L-menthol on in vitro permeation were screened, 3% was added as the amount of permeation enhancer and the 24 h cumulative permeation amount(277.46 ± 15.58 µg/cm²) comparable to that of commercial patch MOHRUS^®(279.74 ± 29.23 µg/cm²). Pharmacokinetic and the tissue distribution study showed no matter in plasma, muscle or skin, the drug concentration of self-made ketoprofen patch was equivalent to that of commercial patch. These data indicated that the self-made patch provided a new reference for the development of ketoprofen dosage forms and promising alternative strategy for analgesic treatment.

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设计和评估用于透皮给药酮洛芬的药贴。

本研究的目的是利用热熔压敏胶作为贴片的基质，设计一种用于透皮给药酮洛芬的 "药中胶（DIA）"贴片。研究了贴片的粘附性能和皮肤渗透性，并评估了贴片的体内药代动力学和组织分布。采用 Holt-melt 法制备了具有高粘附性的新型酮洛芬贴片。筛选了不同比例的左旋薄荷醇对体外渗透的影响，添加 3% 的渗透增强剂，24 h 的累积渗透量（277.46 ± 15.58 µg/cm2）与商用贴片 MOHRUS® 的渗透量（279.74 ± 29.23 µg/cm2）相当。药代动力学和组织分布研究表明，无论是在血浆、肌肉还是皮肤中，自制酮洛芬贴片的药物浓度都与商品贴片相当。这些数据表明，自制贴片为开发酮洛芬剂型提供了一个新的参考，是一种很有前途的镇痛治疗替代策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Drug Delivery and Translational Research MEDICINE, RESEARCH & EXPERIMENTALPHARMACOL-PHARMACOLOGY & PHARMACY

CiteScore

11.70

自引率

1.90%

发文量

160

期刊介绍： The journal provides a unique forum for scientific publication of high-quality research that is exclusively focused on translational aspects of drug delivery. Rationally developed, effective delivery systems can potentially affect clinical outcome in different disease conditions. Research focused on the following areas of translational drug delivery research will be considered for publication in the journal. Designing and developing novel drug delivery systems, with a focus on their application to disease conditions; Preclinical and clinical data related to drug delivery systems; Drug distribution, pharmacokinetics, clearance, with drug delivery systems as compared to traditional dosing to demonstrate beneficial outcomes Short-term and long-term biocompatibility of drug delivery systems, host response; Biomaterials with growth factors for stem-cell differentiation in regenerative medicine and tissue engineering; Image-guided drug therapy, Nanomedicine; Devices for drug delivery and drug/device combination products. In addition to original full-length papers, communications, and reviews, the journal includes editorials, reports of future meetings, research highlights, and announcements pertaining to the activities of the Controlled Release Society.