{"title":"Age-associated changes in gene regulatory relationships affect basic cellular processes","authors":"","doi":"10.1038/s43587-024-00706-z","DOIUrl":null,"url":null,"abstract":"We quantified age-related changes in gene regulatory relationships across eight human tissues. Our results reveal that the gene–gene relationships that become stronger with age affect mostly genes that operate on the same cellular processes, whereas relationships that become weaker affect genes involved in different processes.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":"4 10","pages":"1348-1349"},"PeriodicalIF":17.0000,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature aging","FirstCategoryId":"1085","ListUrlMain":"https://www.nature.com/articles/s43587-024-00706-z","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
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Abstract
We quantified age-related changes in gene regulatory relationships across eight human tissues. Our results reveal that the gene–gene relationships that become stronger with age affect mostly genes that operate on the same cellular processes, whereas relationships that become weaker affect genes involved in different processes.
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