Horizontal cortical connections shape intrinsic traveling waves into feature-selective motifs that regulate perceptual sensitivity.

Abstract

Intrinsic cortical activity forms traveling waves that modulate sensory-evoked responses and perceptual sensitivity. These intrinsic traveling waves (iTWs) may arise from the coordination of synaptic activity through long-range feature-dependent horizontal connectivity within cortical areas. In a spiking network model that incorporates feature-selective patchy connections, we observe iTW motifs that result from shifts in excitatory/inhibitory balance as action potentials traverse these patchy connections. To test whether feature-selective motifs occur in vivo, we examined data recorded in the middle temporal visual area (Area MT) of marmosets performing a visual detection task. We find that some iTWs form motifs that are feature selective, exhibiting direction-selective modulations in spiking activity. Further, motifs modulate the gain of target-evoked responses and perceptual sensitivity if the target matches the preference of the motif. These results suggest that iTWs are shaped by the patchy horizontal fiber projections in the cortex and can regulate neural and perceptual sensitivity in a feature-selective manner.