Misdiagnosis of Multiple Sclerosis: Past, Present, and Future.

IF 4.8 2区 医学 Q1 CLINICAL NEUROLOGY Current Neurology and Neuroscience Reports Pub Date : 2024-11-01 Epub Date: 2024-09-07 DOI:10.1007/s11910-024-01371-w
Nicole Bou Rjeily, Andrew J Solomon
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Abstract

Purpose of review: Misdiagnosis of multiple sclerosis (MS) is a prevalent worldwide problem. This review discusses how MS misdiagnosis has evolved over time and focuses on contemporary challenges and potential strategies for its prevention.

Recent findings: Recent studies report cohorts with a range of misdiagnosis between 5 and 18%. Common disorders are frequently misdiagnosed as MS. Overreliance on MRI findings and misapplication of MS diagnostic criteria are often associated with misdiagnosis. Emerging imaging biomarkers, including the central vein sign and paramagnetic rim lesions, may aid diagnostic accuracy when evaluating patients for suspected MS. MS misdiagnosis can have harmful consequences for patients and healthcare systems. Further research is needed to better understand its causes. Concerted and novel educational efforts to ensure accurate and widespread implementation of MS diagnostic criteria remain an unmet need. The incorporation of diagnostic biomarkers highly specific for MS in the future may prevent misdiagnosis.

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多发性硬化症的误诊:过去、现在和未来。
审查目的:多发性硬化症(MS)的误诊是一个普遍存在的世界性问题。这篇综述讨论了多发性硬化症误诊随着时间的推移是如何演变的,并重点探讨了当代的挑战和预防误诊的潜在策略:最近的研究报告显示,误诊率在 5% 到 18% 之间。常见疾病经常被误诊为多发性硬化症。过度依赖核磁共振成像结果和误用多发性硬化症诊断标准往往与误诊有关。在对疑似多发性硬化症患者进行评估时,包括中央静脉征和顺磁性边缘病变在内的新兴成像生物标志物可能有助于提高诊断的准确性。多发性硬化症误诊会给患者和医疗系统带来有害后果。要更好地了解其原因,还需要进一步的研究。为确保多发性硬化症诊断标准的准确和广泛实施而开展的协调一致的新型教育工作仍是一项尚未满足的需求。未来纳入对多发性硬化症具有高度特异性的诊断生物标志物可能会避免误诊。
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来源期刊
CiteScore
9.20
自引率
0.00%
发文量
73
审稿时长
6-12 weeks
期刊介绍: Current Neurology and Neuroscience Reports provides in-depth review articles contributed by international experts on the most significant developments in the field. By presenting clear, insightful, balanced reviews that emphasize recently published papers of major importance, the journal elucidates current and emerging approaches to the diagnosis, treatment, management, and prevention of neurological disease and disorders. Presents the views of experts on current advances in neurology and neuroscience Gathers and synthesizes important recent papers on the topic Includes reviews of recently published clinical trials, valuable web sites, and commentaries from well-known figures in the field.
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