Asprosin-mediated regulation of ovarian functions in mice: An age-dependent study

IF 2.8 4区医学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Peptides Pub Date : 2024-09-05 DOI:10.1016/j.peptides.2024.171293

{"title":"Asprosin-mediated regulation of ovarian functions in mice: An age-dependent study","authors":"","doi":"10.1016/j.peptides.2024.171293","DOIUrl":null,"url":null,"abstract":"<div>Asprosin is a recently discovered adipokine reported to be involved in the modulation of mammalian gonadal functions. Preliminary investigations suggest its role in regulation of ovarian functions in rodents as well as bovids. In addition, increased levels of the adipokine during human ovarian pathophysiologies implicate it in disease progression and severity. The present study evidenced high expression of asprosin in ovaries of juvenile, pubertal and adult mice while expression was significantly low in ageing ovaries. Further, asprosin stimulated expression of markers for ovarian folliculogenesis (Scf, c-Kit, Gdf9, Bmp6, Fshr, Lhr) and steroidogenesis (3β-Hsd) in adult mice. In addition to exploring concentration-dependent effect of asprosin, the study implicates asprosin as an age-dependent modulator of ovarian functions as treatment of ovaries with asprosin led to upregulation of Fshr, c-Kit, Bmp6, and Gdf9 in both adult and juvenile ovaries, Lhr only in adults while that of Scf only in juvenile ovaries. The current study is first to report an age-dependent expression and role of asprosin in murine ovaries.</div>","PeriodicalId":19765,"journal":{"name":"Peptides","volume":null,"pages":null},"PeriodicalIF":2.8000,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Peptides","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0196978124001463","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Asprosin is a recently discovered adipokine reported to be involved in the modulation of mammalian gonadal functions. Preliminary investigations suggest its role in regulation of ovarian functions in rodents as well as bovids. In addition, increased levels of the adipokine during human ovarian pathophysiologies implicate it in disease progression and severity. The present study evidenced high expression of asprosin in ovaries of juvenile, pubertal and adult mice while expression was significantly low in ageing ovaries. Further, asprosin stimulated expression of markers for ovarian folliculogenesis (Scf, c-Kit, Gdf9, Bmp6, Fshr, Lhr) and steroidogenesis (3β-Hsd) in adult mice. In addition to exploring concentration-dependent effect of asprosin, the study implicates asprosin as an age-dependent modulator of ovarian functions as treatment of ovaries with asprosin led to upregulation of Fshr, c-Kit, Bmp6, and Gdf9 in both adult and juvenile ovaries, Lhr only in adults while that of Scf only in juvenile ovaries. The current study is first to report an age-dependent expression and role of asprosin in murine ovaries.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

阿司匹林介导的小鼠卵巢功能调节：一项年龄依赖性研究。

据报道，阿司匹林是最近发现的一种参与哺乳动物性腺功能调节的脂肪因子。初步研究表明，它在啮齿动物和牛的卵巢功能调节中发挥作用。此外，在人类卵巢病理生理过程中，脂肪因子水平的升高也与疾病的进展和严重程度有关。本研究表明，天冬氨酸在幼鼠、青春期小鼠和成年小鼠卵巢中的表达量较高，而在老龄小鼠卵巢中的表达量则明显较低。此外，天冬氨酸还能刺激成年小鼠卵巢卵泡生成标志物（Scf、c-Kit、Gdf9、Bmp6、Fshr、Lhr）和类固醇生成标志物（3β-Hsd）的表达。除了探索芦荟素的浓度依赖性效应外，该研究还表明芦荟素是一种年龄依赖性卵巢功能调节剂，因为用芦荟素处理卵巢会导致成年和幼年卵巢中的Fshr、c-Kit、Bmp6和Gdf9上调，而Lhr仅在成年卵巢中上调，Scf仅在幼年卵巢中上调。本研究首次报道了天冬氨酸在小鼠卵巢中随年龄变化的表达和作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Peptides 医学-生化与分子生物学

CiteScore

6.40

自引率

6.70%

发文量

130

审稿时长

28 days

期刊介绍： Peptides is an international journal presenting original contributions on the biochemistry, physiology and pharmacology of biological active peptides, as well as their functions that relate to gastroenterology, endocrinology, and behavioral effects. Peptides emphasizes all aspects of high profile peptide research in mammals and non-mammalian vertebrates. Special consideration can be given to plants and invertebrates. Submission of articles with clinical relevance is particularly encouraged.

期刊最新文献

R-954, a bradykinin B1 receptor antagonist, as a potential therapy in a preclinical endometriosis model Mas receptor blockade impairs exercise-induced cardiac hypertrophy Asprosin-mediated regulation of ovarian functions in mice: An age-dependent study Serum CIAPIN1 is lower in septic patients with cardiac dysfunction Editorial Board