G protein coupled receptor in apoptosis and apoptotic cell clearance

IF 2.5 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY FASEB bioAdvances Pub Date : 2024-08-06 DOI:10.1096/fba.2024-00067
Xinyan Li, Chao Li, Yang Kang, Rui Zhang, Peiyao Li, Qian Zheng, Hui Wang, Hui Xiao, Lei Yuan
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Abstract

Apoptosis is a genetically programmed form of cell death that is substantially conserved across the evolutionary tree. Apoptotic cell elimination includes recognition, phagocytosis, and degradation. Failure to clear apoptotic cells can ultimately cause a series of human diseases, such as systemic lupus erythematosus, Alzheimer's disease, atherosclerosis, and cancer. Consequently, the timely and effective removal of apoptotic cells is crucial to maintaining the body's homeostasis. GPCRs belong to the largest membrane receptor family. Its intracellular domain exerts an effect on the trimer G protein. By combining with a variety of ligands, the extracellular domain of G protein initiates the dissociation of G protein trimers and progressively transmits signals downstream. Presently, numerous G protein-coupled receptors (GPCRs) have been identified as participants in the apoptosis signal transduction pathway and the apoptotic cell clearance pathway. Therefore, studies on the mechanism of GPCRs in the clearance of apoptotic cells is important for the development of GPCRs therapeutics.

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细胞凋亡和凋亡细胞清除中的 G 蛋白偶联受体
细胞凋亡是一种基因编程的细胞死亡形式,在整个进化树中基本保持不变。细胞凋亡包括识别、吞噬和降解。如果不能清除凋亡细胞,最终会导致一系列人类疾病,如系统性红斑狼疮、阿尔茨海默病、动脉粥样硬化和癌症。因此,及时有效地清除凋亡细胞对维持机体平衡至关重要。GPCR 属于最大的膜受体家族。它的胞内结构域对三聚体 G 蛋白产生作用。通过与各种配体结合,G 蛋白的胞外结构域启动 G 蛋白三聚体的解离,并逐渐向下游传递信号。目前,许多 G 蛋白偶联受体(GPCR)已被确认为凋亡信号转导途径和凋亡细胞清除途径的参与者。因此,研究 GPCR 在清除凋亡细胞过程中的作用机制对于开发 GPCR 治疗药物非常重要。
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来源期刊
FASEB bioAdvances
FASEB bioAdvances Multiple-
CiteScore
5.40
自引率
3.70%
发文量
56
审稿时长
10 weeks
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