Pathogenic role of anti-nuclear autoantibodies in systemic sclerosis: Insights from other rheumatic diseases.

IF 7.5 2区 医学 Q1 IMMUNOLOGY Immunological Reviews Pub Date : 2024-09-09 DOI:10.1111/imr.13390
Wieke M van Oostveen, Tom W J Huizinga, Cynthia M Fehres
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引用次数: 0

Abstract

Systemic sclerosis (SSc) is a severe autoimmune disease characterized by vasculopathy, fibrosis, and dysregulated immunity, with hallmark autoantibodies targeting nuclear antigens such as centromere protein (ACA) and topoisomerase I (ATA). These autoantibodies are highly prevalent and disease-specific, rarely coexisting, thus serving as crucial biomarkers for SSc diagnosis. Despite their diagnostic value, their roles in SSc pathogenesis remain unclear. This review summarizes current literature on ACA and ATA in SSc, comparing them to autoantibodies in other rheumatic diseases to elucidate their potential pathogenic roles. Similarities are drawn with anti-citrullinated protein antibodies (ACPA) in rheumatoid arthritis, particularly regarding disease specificity and minimal pathogenic impact of antigen binding. In addition, differences between ANA and ACPA in therapeutic responses and Fab glycosylation patterns are reviewed. While ACA and ATA are valuable for disease stratification and monitoring activity, understanding their origins and the associated B cell responses is critical for advancing therapeutic strategies for SSc.

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抗核自身抗体在系统性硬化症中的致病作用:其他风湿病的启示。
系统性硬化症(SSc)是一种严重的自身免疫性疾病,以血管病变、纤维化和免疫失调为特征,其标志性自身抗体靶向核抗原,如中心粒蛋白(ACA)和拓扑异构酶 I(ATA)。这些自身抗体具有高度流行性和疾病特异性,很少同时存在,因此是诊断 SSc 的重要生物标志物。尽管这些抗体具有诊断价值,但它们在 SSc 发病机制中的作用仍不明确。本综述总结了目前有关 SSc 中 ACA 和 ATA 的文献,并将它们与其他风湿性疾病中的自身抗体进行了比较,以阐明它们的潜在致病作用。它们与类风湿性关节炎中的抗瓜氨酸蛋白抗体(ACPA)有相似之处,特别是在疾病特异性和抗原结合的最小致病影响方面。此外,还回顾了 ANA 和 ACPA 在治疗反应和 Fab 糖基化模式方面的差异。虽然 ACA 和 ATA 对于疾病分层和监测活动很有价值,但了解它们的起源和相关的 B 细胞反应对于推进 SSc 的治疗策略至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Immunological Reviews
Immunological Reviews 医学-免疫学
CiteScore
16.20
自引率
1.10%
发文量
118
审稿时长
4-8 weeks
期刊介绍: Immunological Reviews is a specialized journal that focuses on various aspects of immunological research. It encompasses a wide range of topics, such as clinical immunology, experimental immunology, and investigations related to allergy and the immune system. The journal follows a unique approach where each volume is dedicated solely to a specific area of immunological research. However, collectively, these volumes aim to offer an extensive and up-to-date overview of the latest advancements in basic immunology and their practical implications in clinical settings.
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