Elevated risk of adverse effects from foodborne contaminants and drugs in inflammatory bowel disease: a review

IF 4.8 2区 医学 Q1 TOXICOLOGY Archives of Toxicology Pub Date : 2024-09-09 DOI:10.1007/s00204-024-03844-w
Tom Walraven, Mathias Busch, Jingxuan Wang, Joanne M. Donkers, Marjolijn Duijvestein, Evita van de Steeg, Nynke I. Kramer, Hans Bouwmeester
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Abstract

The global burden of Inflammatory bowel disease (IBD) has been rising over the last decades. IBD is an intestinal disorder with a complex and largely unknown etiology. The disease is characterized by a chronically inflamed gastrointestinal tract, with intermittent phases of exacerbation and remission. This compromised intestinal barrier can contribute to, enhance, or even enable the toxicity of drugs, food-borne chemicals and particulate matter. This review discusses whether the rising prevalence of IBD in our society warrants the consideration of IBD patients as a specific population group in toxicological safety assessment. Various in vivo, ex vivo and in vitro models are discussed that can simulate hallmarks of IBD and may be used to study the effects of prevalent intestinal inflammation on the hazards of these various toxicants. In conclusion, risk assessments based on healthy individuals may not sufficiently cover IBD patient safety and it is suggested to consider this susceptible subgroup of the population in future toxicological assessments.

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炎症性肠病患者受到食源性污染物和药物不良影响的风险升高:综述。
过去几十年来,全球炎症性肠病(IBD)的发病率不断上升。IBD 是一种病因复杂且大多不明的肠道疾病。该病的特点是胃肠道长期发炎,间歇性加重和缓解。这种受损的肠道屏障可导致、增强甚至促成药物、食源性化学物质和微粒物质的毒性。本综述讨论了随着 IBD 在社会中发病率的上升,是否有必要在毒理学安全性评估中将 IBD 患者作为一个特殊的人群来考虑。文中讨论了各种体内、体外和体外模型,这些模型可以模拟 IBD 的特征,并可用于研究普遍存在的肠道炎症对各种毒物危害的影响。总之,基于健康人的风险评估可能不足以涵盖 IBD 患者的安全,建议在未来的毒理学评估中考虑到这一易感人群。
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来源期刊
Archives of Toxicology
Archives of Toxicology 医学-毒理学
CiteScore
11.60
自引率
4.90%
发文量
218
审稿时长
1.5 months
期刊介绍: Archives of Toxicology provides up-to-date information on the latest advances in toxicology. The journal places particular emphasis on studies relating to defined effects of chemicals and mechanisms of toxicity, including toxic activities at the molecular level, in humans and experimental animals. Coverage includes new insights into analysis and toxicokinetics and into forensic toxicology. Review articles of general interest to toxicologists are an additional important feature of the journal.
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