Past, Present, and Future Biomarkers of Kidney Function and Injury: The Relationship With Antibiotics

IF 4.9 2区 医学 Q1 INFECTIOUS DISEASES International Journal of Antimicrobial Agents Pub Date : 2024-09-07 DOI:10.1016/j.ijantimicag.2024.107332
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Abstract

Routinely used kidney biomarkers of injury and function such as serum creatinine and urine albumin to creatinine ratio, are neither sensitive nor specific. Future biomarkers are being developed for clinical use and have already been included in guidance from groups such as the U.S. Food and Drug Administration and the Predictive Safety Testing Consortium. These biomarkers have important implications for early identification of kidney injury and more accurate measurement of kidney function. Many antibiotics are either eliminated by the kidney or can cause clinically significant nephrotoxicity. As a result, clinicians should be familiar with new biomarkers of kidney function and injury, their place in clinical practice, and applications for antibiotic dosing.
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肾功能和肾损伤的过去、现在和未来生物标志物:与抗生素的关系。
常规使用的肾脏损伤和功能生物标志物,如血清肌酐和尿白蛋白与肌酐比值,既不敏感也不特异。目前正在开发用于临床的未来生物标志物,并已将其纳入美国食品药品管理局和预测安全性测试联盟等组织的指南中。这些生物标志物对于早期识别肾损伤和更准确地测量肾功能具有重要意义。许多抗生素要么会被肾脏排出体外,要么会引起明显的临床肾毒性。因此,临床医生应该熟悉肾功能和肾损伤的新生物标记物、它们在临床实践中的地位以及在抗生素剂量中的应用。
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来源期刊
CiteScore
21.60
自引率
0.90%
发文量
176
审稿时长
36 days
期刊介绍: The International Journal of Antimicrobial Agents is a peer-reviewed publication offering comprehensive and current reference information on the physical, pharmacological, in vitro, and clinical properties of individual antimicrobial agents, covering antiviral, antiparasitic, antibacterial, and antifungal agents. The journal not only communicates new trends and developments through authoritative review articles but also addresses the critical issue of antimicrobial resistance, both in hospital and community settings. Published content includes solicited reviews by leading experts and high-quality original research papers in the specified fields.
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