Choroid plexus enlargement correlates with periventricular pathology but not with disease activity in radiologically isolated syndrome.

IF 4.8 2区 医学 Q1 CLINICAL NEUROLOGY Multiple Sclerosis Journal Pub Date : 2024-09-01 Epub Date: 2024-09-09 DOI:10.1177/13524585241272943
Cassandre Landes-Château, Vito Ag Ricigliano, Lydiane Mondot, Eric Thouvenot, Pierre Labauge, Céline Louapre, Hélène Zéphir, Françoise Durand-Dubief, Emmanuelle Le Page, Aksel Siva, Mikael Cohen, Arya Yazdan Panah, Christina J Azevedo, Darin T Okuda, Bruno Stankoff, Christine Lebrun-Frénay
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Abstract

Background: Choroid plexus (ChP) enlargement is an emerging radiological biomarker in multiple sclerosis (MS).

Objectives: This study aims to assess ChP volume in a large cohort of patients with radiologically isolated syndrome (RIS) versus healthy controls (HC) and explore its relationship with other brain volumes, disease activity, and biological markers.

Methods: RIS individuals were included retrospectively and compared with HC. ChPs were automatically segmented using an in-house automated algorithm and manually corrected.

Results: A total of 124 patients fulfilled the 2023 RIS criteria, and 55 HCs were included. We confirmed that ChPs are enlarged in RIS versus HC (mean (±SD) normalized ChP volume: 17.24 (±4.95) and 11.61 (±3.58), respectively, p < 0.001). Larger ChPs were associated with more periventricular lesions (ρ = 0.26; r2 = 0.27; p = 0.005 for the correlation with lesion volume, and ρ = 0.2; r2 = 0.21; p = 0.002 for the correlation with lesion number) and lower thalamic volume (ρ = -0.38; r2 = 0.44; p < 0.001), but not with lesions in other brain regions. Conversely, ChP volume did not correlate with biological markers. No significant difference in ChP volume was observed between subjects who presented or did not have a clinical event or between those with or without imaging disease activity.

Conclusions: This study provides evidence that ChP volume is higher in RIS and is associated with measures reflecting periventricular pathology but does not correlate with biological, radiological, or clinical markers of disease activity.

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脉络丛扩大与脑室周围病变相关,但与放射学孤立综合征的疾病活动无关。
背景:脉络丛(Choroid plexus,ChP)增大是多发性硬化症(MS)新出现的放射学生物标志物:本研究旨在评估一大批放射学孤立综合征(RIS)患者与健康对照组(HC)的脉络丛体积,并探讨其与其他脑体积、疾病活动性和生物标记物的关系:方法:回顾性纳入 RIS 患者,并与 HC 进行比较。采用内部自动算法自动分割 ChPs,并进行人工校正:结果:共有 124 名患者符合 2023 年 RIS 标准,其中包括 55 名 HC 患者。我们证实,与 HC 相比,RIS 患者的 ChPs 增大(平均(±SD)归一化 ChP 体积:分别为 17.24 (±4.95) 和 11.61 (±3.58),p < 0.001)。较大的 ChP 与更多的脑室周围病变相关(ρ = 0.26;r2 = 0.27;与病变体积相关,p = 0.005;ρ = 0.2;r2 = 0.21;与病变数目相关,p = 0.002),丘脑体积较小(ρ = -0.38;r2 = 0.44;p < 0.001),但与其他脑区的病变无关。相反,丘脑体积与生物标记物没有相关性。在出现或未出现临床事件的受试者之间,或在有或无影像学疾病活动的受试者之间,均未观察到 ChP 体积的明显差异:本研究提供的证据表明,RIS 患者的 ChP 体积较大,且与反映脑室周围病变的指标相关,但与疾病活动的生物学、放射学或临床指标无关。
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来源期刊
Multiple Sclerosis Journal
Multiple Sclerosis Journal 医学-临床神经学
CiteScore
10.90
自引率
6.90%
发文量
186
审稿时长
3-8 weeks
期刊介绍: Multiple Sclerosis Journal is a peer-reviewed international journal that focuses on all aspects of multiple sclerosis, neuromyelitis optica and other related autoimmune diseases of the central nervous system. The journal for your research in the following areas: * __Biologic basis:__ pathology, myelin biology, pathophysiology of the blood/brain barrier, axo-glial pathobiology, remyelination, virology and microbiome, immunology, proteomics * __Epidemology and genetics:__ genetics epigenetics, epidemiology * __Clinical and Neuroimaging:__ clinical neurology, biomarkers, neuroimaging and clinical outcome measures * __Therapeutics and rehabilitation:__ therapeutics, rehabilitation, psychology, neuroplasticity, neuroprotection, and systematic management Print ISSN: 1352-4585
期刊最新文献
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