Progression independent of relapse activity can be predicted by passively acquired tapping speed through a smartphone for 1 month: A prospective study.

IF 4.8 2区 医学 Q1 CLINICAL NEUROLOGY Multiple Sclerosis Journal Pub Date : 2024-09-01 Epub Date: 2024-09-09 DOI:10.1177/13524585241272960
Juan Luis Chico-Garcia, Raquel Sainz Amo, Enric Monreal, Susana Sainz de la Maza, Fernando Rodriguez Jorge, Jaime Masjuan, Lucienne Costa-Frossard, Luisa María Villar
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Abstract

Background: Tapping speed (TS) correlates with baseline disability scales in people with multiple sclerosis (pwMS).

Objective: The study aimed to address if progression independent of relapse activity (PIRA) could be predicted by first-month measurement of TS.

Methods: Prospective study including pwMS in one referral MS center. Consecutive patients were included and keys/second (Keys/s) were passively measured each day using an in-house smartphone application for 1 month. Median, mean, and maximum keys/s were obtained. Multivariate logistic regression models (including keys/s, age, sex, and baseline disability scores) were obtained for prediction of a PIRA event after 1 year.

Results: Overall, 59 patients were included in the final analysis (64.4% women, median age of 44.5 years). However, 10 patients presented a PIRA event, without differences regarding baseline characteristics between PIRA and no-PIRA groups. PIRA group presented lower median keys/s (2 vs 4 keys/s, p = 0.002) and mean keys/s (2.8 vs 4.6, p = 0.008), while maximum keys/s were similar (p = 0.32). A median ⩽ 3 keys/s was independently associated with PIRA (aOR = 16.8, p = 0.03), as did a mean ⩽ 3.7 keys/s (aOR = 17, p = 0.02). These differences were not detected regarding other variables analyzed.

Conclusion: Low median or mean keys/s obtained during initial month of assessment were indicative of a PIRA event within the next year.

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通过智能手机在 1 个月内被动获取的敲击速度,可以预测与复发活动无关的病情进展:一项前瞻性研究。
背景:拍打速度(TS)与多发性硬化症患者的基线残疾量表相关:攻丝速度(TS)与多发性硬化症患者(pwMS)的基线残疾量表相关:该研究旨在探讨是否可以通过第一个月的拍打速度测量来预测独立于复发活动的进展(PIRA):方法:前瞻性研究,包括一家多发性硬化症转诊中心的多发性硬化症患者。连续纳入患者,每天使用内部智能手机应用程序被动测量键/秒(Keys/s),为期一个月。得出键/秒的中位数、平均值和最大值。多变量逻辑回归模型(包括按键/秒、年龄、性别和基线残疾评分)用于预测 1 年后的 PIRA 事件:共有 59 名患者纳入最终分析(64.4% 为女性,中位年龄为 44.5 岁)。但有 10 名患者出现了 PIRA 事件,PIRA 组和非 PIRA 组的基线特征没有差异。PIRA 组的中位按键/秒(2 vs 4 键/秒,p = 0.002)和平均按键/秒(2.8 vs 4.6 键/秒,p = 0.008)较低,而最大按键/秒相似(p = 0.32)。中位数⩽ 3 键/秒与 PIRA 独立相关(aOR = 16.8,p = 0.03),平均值⩽ 3.7 键/秒也与 PIRA 独立相关(aOR = 17,p = 0.02)。在分析的其他变量中未发现这些差异:结论:在评估的最初一个月中获得的按键/秒中位数或平均值较低,表明在接下来的一年中可能会发生 PIRA 事件。
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来源期刊
Multiple Sclerosis Journal
Multiple Sclerosis Journal 医学-临床神经学
CiteScore
10.90
自引率
6.90%
发文量
186
审稿时长
3-8 weeks
期刊介绍: Multiple Sclerosis Journal is a peer-reviewed international journal that focuses on all aspects of multiple sclerosis, neuromyelitis optica and other related autoimmune diseases of the central nervous system. The journal for your research in the following areas: * __Biologic basis:__ pathology, myelin biology, pathophysiology of the blood/brain barrier, axo-glial pathobiology, remyelination, virology and microbiome, immunology, proteomics * __Epidemology and genetics:__ genetics epigenetics, epidemiology * __Clinical and Neuroimaging:__ clinical neurology, biomarkers, neuroimaging and clinical outcome measures * __Therapeutics and rehabilitation:__ therapeutics, rehabilitation, psychology, neuroplasticity, neuroprotection, and systematic management Print ISSN: 1352-4585
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