Recording and reporting of ultra-high dose rate “FLASH” delivery for preclinical and clinical settings

IF 4.9 1区 医学 Q1 ONCOLOGY Radiotherapy and Oncology Pub Date : 2024-09-06 DOI:10.1016/j.radonc.2024.110507
Till Tobias Böhlen , Serena Psoroulas , Jack D Aylward , Sam Beddar , Alexandros Douralis , Grégory Delpon , Cristina Garibaldi , Alessia Gasparini , Emil Schüler , Frank Stephan , Raphaël Moeckli , Anna Subiel
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Abstract

Treatments at ultra-high dose rate (UHDR) have the potential to improve the therapeutic index of radiation therapy (RT) by sparing normal tissues compared to conventional dose rate irradiations. Insufficient and inconsistent reporting in physics and dosimetry of preclinical and translational studies may have contributed to a reproducibility crisis of radiobiological data in the field. Consequently, the development of a common terminology, as well as common recording, reporting, dosimetry, and metrology standards is required. In the context of UHDR irradiations, the temporal dose delivery parameters are of importance, and under-reporting of these parameters is also a concern.This work proposes a standardization of terminology, recording, and reporting to enhance comparability of both preclinical and clinical UHDR studies and and to allow retrospective analyses to aid the understanding of the conditions which give rise to the FLASH effect.

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为临床前和临床环境记录和报告超高剂量率 "FLASH "输送。
与传统剂量率辐照相比,超高剂量率(UHDR)辐照可保护正常组织,从而提高放射治疗(RT)的治疗指数。临床前和转化研究的物理学和剂量学报告不足且不一致,可能导致该领域放射生物学数据的可重复性危机。因此,需要制定通用术语以及通用记录、报告、剂量测定和计量标准。这项工作提出了术语、记录和报告的标准化,以提高临床前和临床超高剂量辐照研究的可比性,并允许进行回顾性分析,以帮助了解产生闪烁效应的条件。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Radiotherapy and Oncology
Radiotherapy and Oncology 医学-核医学
CiteScore
10.30
自引率
10.50%
发文量
2445
审稿时长
45 days
期刊介绍: Radiotherapy and Oncology publishes papers describing original research as well as review articles. It covers areas of interest relating to radiation oncology. This includes: clinical radiotherapy, combined modality treatment, translational studies, epidemiological outcomes, imaging, dosimetry, and radiation therapy planning, experimental work in radiobiology, chemobiology, hyperthermia and tumour biology, as well as data science in radiation oncology and physics aspects relevant to oncology.Papers on more general aspects of interest to the radiation oncologist including chemotherapy, surgery and immunology are also published.
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