Sensitivity Analysis of C. auris, S. cerevisiae, and C. cladosporioides by Irradiation with Far-UVC, UVC, and UVB.

Q1 Medicine Pathogens and Immunity Pub Date : 2024-08-21 eCollection Date: 2024-01-01 DOI:10.20411/pai.v9i2.723
Anna-Maria Gierke, Martin Hessling
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Abstract

Background: The World Health Organization has published a list of pathogenic fungi with prior-itizing groups and calls for research and development of antifungal measures, with Candida auris belonging to the group with high priority.

Methods: The photosensitivity towards short wavelength ultraviolet irradiation (Far-UVC, UVC, and UVB) was investigated and compared to other yeasts (Saccharomyces cerevisiae) and a mold (Cladosporium cladosporioides). The observed 1-log reduction doses were compared to literature values of other representatives of the genus Candida, but also with S. cerevisiae, Aspergillus niger, and A. fumigatus.

Results: For the determined 1-log reduction doses, an increase with higher wavelengths was observed. A 1-log reduction dose of 4.3 mJ/cm2 was determined for C. auris when irradiated at 222 nm, a dose of 6.1 mJ/cm2 at 254 nm and a 1-log reduction dose of 51.3 mJ/cm2 was required when irradiated with UVB.

Conclusions: It was observed that S. cerevisiae is a possible surrogate for C. auris for irradiation with Far-UVC and UVB due to close 1-log reduction doses. No surrogate suitability was verified for C. cladosporioides in relation to A. niger and A. fumigatus for irradiation with a wavelength of 254 nm and for A. niger at 222 nm.

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用远紫外线、紫外线和紫外线辐照 C. auris、S. cerevisiae 和 C. cladosporioides 的敏感性分析。
背景:世界卫生组织公布了一份致病真菌优先群体名单,呼吁研究和开发抗真菌措施,白色念珠菌属于优先群体:方法:研究了白色念珠菌对短波紫外线照射(远紫外线、紫外线和紫外线)的光敏性,并与其他酵母菌(酿酒酵母)和霉菌(Cladosporium cladosporioides)进行了比较。观察到的 1-log降低剂量与其他念珠菌属代表菌种的文献值进行了比较,同时也与酿酒酵母、黑曲霉和烟曲霉进行了比较:结果:在确定的 1-log还原剂量中,观察到波长越高,剂量越大。在 222 纳米波长下照射 C. auris,1-log 减少剂量为 4.3 mJ/cm2;在 254 纳米波长下照射 C. auris,1-log 减少剂量为 6.1 mJ/cm2;在 UVB 波长下照射 C. auris,1-log 减少剂量为 51.3 mJ/cm2:结论:研究发现,由于远紫外和紫外线的1-log减少剂量接近,谷氨酸酵母菌可能是用远紫外和紫外线照射C.在波长为 254 纳米和 222 纳米的辐照条件下,C. cladosporioides 与 A. niger 和 A. fumigatus 的代用性未得到验证。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Pathogens and Immunity
Pathogens and Immunity Medicine-Infectious Diseases
CiteScore
10.60
自引率
0.00%
发文量
16
审稿时长
10 weeks
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