{"title":"Sensitivity Analysis of <i>C. auris, S. cerevisiae</i>, and <i>C. cladosporioides</i> by Irradiation with Far-UVC, UVC, and UVB.","authors":"Anna-Maria Gierke, Martin Hessling","doi":"10.20411/pai.v9i2.723","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>The World Health Organization has published a list of pathogenic fungi with prior-itizing groups and calls for research and development of antifungal measures, with <i>Candida auris</i> belonging to the group with high priority.</p><p><strong>Methods: </strong>The photosensitivity towards short wavelength ultraviolet irradiation (Far-UVC, UVC, and UVB) was investigated and compared to other yeasts (<i>Saccharomyces cerevisiae</i>) and a mold (<i>Cladosporium cladosporioides</i>). The observed 1-log reduction doses were compared to literature values of other representatives of the genus <i>Candida</i>, but also with <i>S. cerevisiae, Aspergillus niger,</i> and <i>A. fumigatus</i>.</p><p><strong>Results: </strong>For the determined 1-log reduction doses, an increase with higher wavelengths was observed. A 1-log reduction dose of 4.3 mJ/cm<sup>2</sup> was determined for <i>C. auris</i> when irradiated at 222 nm, a dose of 6.1 mJ/cm<sup>2</sup> at 254 nm and a 1-log reduction dose of 51.3 mJ/cm<sup>2</sup> was required when irradiated with UVB.</p><p><strong>Conclusions: </strong>It was observed that <i>S. cerevisiae</i> is a possible surrogate for <i>C. auris</i> for irradiation with Far-UVC and UVB due to close 1-log reduction doses. No surrogate suitability was verified for <i>C. cladosporioides</i> in relation to <i>A. niger</i> and <i>A. fumigatus</i> for irradiation with a wavelength of 254 nm and for <i>A. niger</i> at 222 nm.</p>","PeriodicalId":36419,"journal":{"name":"Pathogens and Immunity","volume":"9 2","pages":"135-151"},"PeriodicalIF":0.0000,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11378758/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pathogens and Immunity","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.20411/pai.v9i2.723","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"Medicine","Score":null,"Total":0}
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Abstract
Background: The World Health Organization has published a list of pathogenic fungi with prior-itizing groups and calls for research and development of antifungal measures, with Candida auris belonging to the group with high priority.
Methods: The photosensitivity towards short wavelength ultraviolet irradiation (Far-UVC, UVC, and UVB) was investigated and compared to other yeasts (Saccharomyces cerevisiae) and a mold (Cladosporium cladosporioides). The observed 1-log reduction doses were compared to literature values of other representatives of the genus Candida, but also with S. cerevisiae, Aspergillus niger, and A. fumigatus.
Results: For the determined 1-log reduction doses, an increase with higher wavelengths was observed. A 1-log reduction dose of 4.3 mJ/cm2 was determined for C. auris when irradiated at 222 nm, a dose of 6.1 mJ/cm2 at 254 nm and a 1-log reduction dose of 51.3 mJ/cm2 was required when irradiated with UVB.
Conclusions: It was observed that S. cerevisiae is a possible surrogate for C. auris for irradiation with Far-UVC and UVB due to close 1-log reduction doses. No surrogate suitability was verified for C. cladosporioides in relation to A. niger and A. fumigatus for irradiation with a wavelength of 254 nm and for A. niger at 222 nm.
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