Cord Blood 25-Hydroxyvitamin D Level is Correlated with a Risk for Atopic Dermatitis: Systematic Review and Meta-Analysis.

IF 1.1 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Malaysian Journal of Medical Sciences Pub Date : 2024-08-01 Epub Date: 2024-08-27 DOI:10.21315/mjms2024.31.4.4
Dedianto Hidajat, Abiyyu Didar Haq, Cut Warnaini, Hamsu Kadriyan
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Abstract

Although Indonesia is located in an equatorial region with adequate year-round sun exposure, the prevalence of 25-hydroxyvitamin D (25[OH]D) deficiency is as high as 90%. Mothers are especially vulnerable to deficiencies due to changes in their gastrointestinal system. Previous studies have reported a correlation between the 25[OH]D status of mothers with atopic dermatitis (AD) and their offspring. However, studies investigating maternal cord blood 25[OH]D levels and the incidence of AD have yielded controversial results due to its variability. As such, this systematic review and meta-analysis aimed to evaluate the correlation between maternal cord blood 25[OH]D levels and the risk for AD. In accordance with Preferred Reporting System for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, the PubMed, Cochrane Library and ScienceDirect databases were searched for relevant observational studies and a meta-analysis was performed to obtain odds ratios (OR) and corresponding 95% confidence intervals (CI). Nine studies were included in the qualitative synthesis, five of which were included in the quantitative synthesis. Meta-analysis revealed that cord blood 25[OH]D levels < 50 nmol/L were associated with a 60% higher risk for the development of AD (OR = 1.60; 95% CI: 1.15, 2.22; I2 = 0%; P < 0.05). However, qualitative synthesis revealed a variety of cord blood 25[OH]D measurements and different methods of diagnosing AD in each study. Based on the current analysis, maternal cord blood 25[OH]D levels were significantly correlated with the risk for AD. Therefore, studies investigating 25[OH]D supplementation in pregnant women and its efficacy in decreasing the risk for AD are needed, especially in tropical and equatorial countries. This study also serves as a proof of concept that cord blood 25[OH]D levels can be used as a more affordable predictive parameter for AD.

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脐带血 25-羟维生素 D 水平与特应性皮炎风险相关:系统回顾与元分析》。
虽然印度尼西亚地处赤道地区,全年日照充足,但25-羟基维生素D(25[OH]D)缺乏症的发病率却高达90%。由于母亲肠胃系统的变化,她们尤其容易缺乏维生素 D。以往的研究报告显示,特应性皮炎(AD)母亲的 25[OH]D 状态与其后代之间存在相关性。然而,对母体脐带血 25[OH]D 水平和 AD 发病率的研究结果却因其变异性而存在争议。因此,本系统综述和荟萃分析旨在评估母体脐血25[OH]D水平与AD风险之间的相关性。根据系统综述和荟萃分析首选报告系统(PRISMA)指南,我们在PubMed、Cochrane Library和ScienceDirect数据库中搜索了相关的观察性研究,并进行了荟萃分析,得出了几率比(OR)和相应的95%置信区间(CI)。九项研究被纳入定性综述,其中五项被纳入定量综述。元分析显示,脐带血25[OH]D水平< 50 nmol/L与AD发病风险增加60%有关(OR = 1.60; 95% CI: 1.15, 2.22; I2 = 0%; P < 0.05)。然而,定性分析显示,每项研究的脐带血25[OH]D测量值和诊断AD的方法各不相同。根据目前的分析,母体脐血25[OH]D水平与AD风险显著相关。因此,需要对孕妇补充25[OH]D及其降低AD风险的效果进行研究,尤其是在热带和赤道国家。本研究还证明了脐带血中25[OH]D水平可作为更经济的AD预测参数。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Malaysian Journal of Medical Sciences
Malaysian Journal of Medical Sciences MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
2.70
自引率
0.00%
发文量
89
审稿时长
9 weeks
期刊介绍: The Malaysian Journal of Medical Sciences (MJMS) is a peer-reviewed, open-access, fully online journal that is published at least six times a year. The journal’s scope encompasses all aspects of medical sciences including biomedical, allied health, clinical and social sciences. We accept high quality papers from basic to translational research especially from low & middle income countries, as classified by the United Nations & World Bank (https://datahelpdesk.worldbank.org/knowledgebase/ articles/906519), with the aim that published research will benefit back the bottom billion population from these countries. Manuscripts submitted from developed or high income countries to MJMS must contain data and information that will benefit the socio-health and bio-medical sciences of these low and middle income countries. The MJMS editorial board consists of internationally regarded clinicians and scientists from low and middle income countries.
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