The time course of lactate and endocrine changes in dogs suffering from dog bite wounds.

IF 0.9 4区农林科学 Q2 Veterinary Journal of the South African Veterinary Association-Tydskrif Van Die Suid-A Pub Date : 2024-07-18 DOI:10.36303/JSAVA.596

E van Zyl, P N Thompson, J P Schoeman

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Abstract

Background: The stress response after acute trauma in humans and animals has been well-recognised in the literature. However, data on temporal changes in endocrine parameters after acute trauma in previously healthy dogs are scant.

Objective: To longitudinally track endocrine variables and lactate concentrations in dogs with canine bite wounds.

Method: Prospective study involving 20 dogs hospitalised after being bitten by another dog. Serum cortisol, thyroxine (total T4), thyrotropin (TSH), and lactate concentrations were measured on admission and every 8 hours after the recorded bite incident, for a 72-hour period.

Results: Median cortisol concentration was markedly elevated on admission (314.6 nmol/L; IQR 229.3-369.6) but returned to within the reference interval by 16 hours post-bite (99.5 nmol/L; IQR 48.7-225.4) and reached a nadir at 48 hours post-bite (38.5 nmol/L; IQR 32.1-115.9). Median total T4 concentration was within the reference interval on admission (20.6 nmol/L; IQR 12.7-27.9) but decreased below the reference interval by 8 hours (11.0 nmol/L; IQR 5.0-14.1) and reached a nadir 16 hours postbite (7.0 nmol/L; IQR 2.9-19.7), before gradually increasing after 64 hours to reach the reference range by 72 hours. The median TSH concentrations remained within the reference interval throughout the study period. Median lactate concentration was mildly elevated on admission (3.0 mmol/L; IQR 2.0-3.9).

Conclusion: This study produced novel data on the temporal relationships of the hypothalamic-pituitary-adrenal and hypothalamicpituitary- thyroidal axes alterations after an acute traumatic insult in dogs.

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被狗咬伤的狗体内乳酸和内分泌变化的时间过程。

背景：人类和动物在急性创伤后的应激反应已在文献中得到广泛认可。然而，有关以前健康的狗在急性创伤后内分泌参数的时间变化的数据却很少：纵向追踪犬咬伤犬的内分泌变量和乳酸浓度：方法：前瞻性研究，涉及 20 只被其他狗咬伤后住院的狗。在入院时和记录咬伤事件后的 72 小时内，每隔 8 小时测量一次血清皮质醇、甲状腺素（总 T4）、促甲状腺激素（TSH）和乳酸盐浓度：入院时皮质醇浓度中位数明显升高（314.6 nmol/L；IQR 229.3-369.6），但在咬伤后 16 小时恢复到参考区间内（99.5 nmol/L；IQR 48.7-225.4），并在咬伤后 48 小时达到最低点（38.5 nmol/L；IQR 32.1-115.9）。入院时总 T4 浓度中位数在参考范围内（20.6 nmol/L；IQR 12.7-27.9），但在咬伤后 8 小时降至参考范围以下（11.0 nmol/L；IQR 5.0-14.1），并在咬伤后 16 小时达到最低点（7.0 nmol/L；IQR 2.9-19.7），然后在 64 小时后逐渐升高，在 72 小时达到参考范围。在整个研究期间，促甲状腺激素浓度中位数一直保持在参考范围内。入院时乳酸浓度中位数轻度升高（3.0 mmol/L；IQR 2.0-3.9）：本研究提供了狗急性创伤后下丘脑-垂体-肾上腺轴和下丘脑-垂体-甲状腺轴改变时间关系的新数据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of the South African Veterinary Association-Tydskrif Van Die Suid-A 农林科学-兽医学

CiteScore

1.50

自引率

0.00%

发文量

审稿时长

22 weeks

期刊介绍： The Journal of the South African Veterinary Association is a contemporary multi-disciplinary scientific mouthpiece for Veterinary Science in South Africa and abroad. It provides veterinarians in South Africa and elsewhere in the world with current scientific information across the full spectrum of veterinary science. Its content therefore includes reviews on various topics, clinical and non-clinical articles, research articles and short communications as well as case reports and letters.