Design and synthesis of two new thiosemicarbazide based Schiff base metal complexes of nickel (II): DNA binding study and cytotoxicity profile analysis

IF 2.7 3区化学 Q2 CHEMISTRY, INORGANIC & NUCLEAR Inorganica Chimica Acta Pub Date : 2024-08-28 DOI:10.1016/j.ica.2024.122337

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Abstract

Two new nickel (II) substituted thiosemicarbazone Schiff base complexes [Ni(meph)₂] (1) [where H₂meph = (2E)-N-methyl-2-[1-(pyridin-2-yl)ethylidene]hydrazine-1-carbothioamide] and [Ni(hmm)₂](NO₃)₂·2H₂O (2) [where H₂hmm = (2E)-2-[(2-hydroxyphenyl)methylidene]-N-methylhydrazine-1-carbothioamide] have been designed and synthesized by the condensation of 4-methyl-3-thiosemicarbazide with 2-acetylpyridine and salicylaldehyde respectively. Both the metal complexes 1 and 2 are characterized using different available spectroscopic techniques like FT-IR, UV–Vis spectroscopy, elemental analysis, and single crystal X-ray structure analysis. X-ray crystal structure analysis reveal that complex 1 and 2 are octahedral Ni(II) complexes. The calf-thymus CT-DNA-binding property of 1 and 2 has been evaluated by employing UV–Vis and fluorescence spectral titration. All the results show that CT-DNA binds with both nickel(II) complexes 1 and 2. In vitro cytotoxicity activity of complexes 1 and 2 toward A375 and MDA-MB-231 was evaluated using MTT assay and other methods which confirm that both complexes 1 and 2 behave as promising anti-cancer agents.

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设计和合成两种新的硫腙基席夫碱镍 (II) 金属配合物：DNA 结合研究和细胞毒性特征分析

两种新的镍（II）取代的硫代氨基羰基席夫碱配合物[Ni(meph)2]（1）[其中 H2meph = (2E)-N-methyl-2-[1-(pyridin-2-yl)ethylidene]hydrazine- 1-carbothioamide1-硫代甲酰胺]和[Ni(hmm)2](NO3)2-2H2O (2) [其中 H2hmm = (2E)-2-[(2-羟基苯基)亚甲基]-N-甲基肼-1-硫代甲酰胺]。分别是通过 4-甲基-3-硫代氨基甲酰肼与 2-乙酰基吡啶和水杨醛缩合设计和合成的。利用现有的不同光谱技术，如傅立叶变换红外光谱、紫外可见光谱、元素分析和单晶 X 射线结构分析，对金属配合物 1 和 2 进行了表征。X 射线晶体结构分析表明，络合物 1 和 2 是八面体 Ni（II）络合物。利用紫外可见光谱和荧光光谱滴定法评估了复合物 1 和 2 的小牛胸腺 CT-DNA 结合特性。所有结果都表明，CT-DNA 与镍(II)配合物 1 和 2 都能结合。利用 MTT 试验和其他方法评估了复合物 1 和 2 对 A375 和 MDA-MB-231 的体外细胞毒性活性，结果证实复合物 1 和 2 都是很有前途的抗癌剂。

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来源期刊

Inorganica Chimica Acta 化学-无机化学与核化学

CiteScore

6.00

自引率

3.60%

发文量

440

审稿时长

35 days

期刊介绍： Inorganica Chimica Acta is an established international forum for all aspects of advanced Inorganic Chemistry. Original papers of high scientific level and interest are published in the form of Articles and Reviews. Topics covered include: • chemistry of the main group elements and the d- and f-block metals, including the synthesis, characterization and reactivity of coordination, organometallic, biomimetic, supramolecular coordination compounds, including associated computational studies; • synthesis, physico-chemical properties, applications of molecule-based nano-scaled clusters and nanomaterials designed using the principles of coordination chemistry, as well as coordination polymers (CPs), metal-organic frameworks (MOFs), metal-organic polyhedra (MPOs); • reaction mechanisms and physico-chemical investigations computational studies of metalloenzymes and their models; • applications of inorganic compounds, metallodrugs and molecule-based materials. Papers composed primarily of structural reports will typically not be considered for publication.