Characterizing the genomic landscape of colorectal cancer

IF 45.9 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-09-09 DOI:10.1038/s41575-024-00988-z
Jordan Hindson
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描述结直肠癌的基因组特征
发表在《自然》(Nature)上的一项研究阐明了结直肠癌(CRC)的基因组图谱。研究人员对英国十万基因组计划参与者的 CRC 样本进行了全基因组测序。对样本(n = 2,023)的分析确定了>250个CRC的推定驱动基因,并描述了CRC亚群的特征。例如,研究人员将微卫星稳定的 CRC 分成了四个不同的亚组,并确定了罕见 CRC 亚组的特征。此外,他们还确定了突变特征SBS93等基因在CRC中的潜在作用。
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来源期刊
CiteScore
52.30
自引率
0.60%
发文量
147
审稿时长
6-12 weeks
期刊介绍: Nature Reviews Gastroenterology & Hepatology aims to serve as the leading resource for Reviews and commentaries within the scientific and medical communities it caters to. The journal strives to maintain authority, accessibility, and clarity in its published articles, which are complemented by easily understandable figures, tables, and other display items. Dedicated to providing exceptional service to authors, referees, and readers, the editorial team works diligently to maximize the usefulness and impact of each publication. The journal encompasses a wide range of content types, including Research Highlights, News & Views, Comments, Reviews, Perspectives, and Consensus Statements, all pertinent to gastroenterologists and hepatologists. With its broad scope, Nature Reviews Gastroenterology & Hepatology ensures that its articles reach a diverse audience, aiming for the widest possible dissemination of valuable information. Nature Reviews Gastroenterology & Hepatology is part of the Nature Reviews portfolio of journals.
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