Metal-organic frameworks and polymer nanoplatform: Biocompatible and photothermal responsive tribromoethanol anesthetic for mice

IF 4 2区化学 Q2 CHEMISTRY, PHYSICAL Journal of Molecular Structure Pub Date : 2024-09-04 DOI:10.1016/j.molstruc.2024.139925

引用次数: 0

Abstract

Effective anesthesia is crucial for ensuring the validity and reliability of animal experiments. In recent years, tribromoethanol has been widely used for small animal anesthesia. However, direct injection poses risks of overdose, anesthesia instability, and organ damage, affecting experimental reliability and animal welfare. Therefore, developing a safer and more stable delivery system for tribromoethanol is essential. In this study, we first synthesized two complexes using a solvothermal method. Then, we modified the traditional biopolymer PEG to synthesize an amphiphilic block copolymer, Cyanine 7-PEG-DDAT, which was used to coat CP1 and load tribromoethanol (TBE) for structural characterization. We then conducted biological tests on Cyanine 7-PEG-DDAT-CP1@TBE and compared its anesthetic effects in C57BL/6 mice with those of direct tribromoethanol injection. The results provide a reference for the application of tribromoethanol in mouse models and surgeries.

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金属有机框架和聚合物纳米平台：用于小鼠的生物相容性和光热响应型三溴乙醇麻醉剂

有效的麻醉对于确保动物实验的有效性和可靠性至关重要。近年来，三溴乙醇被广泛用于小动物麻醉。然而，直接注射存在用药过量、麻醉不稳定和器官损伤等风险，影响实验可靠性和动物福利。因此，开发一种更安全、更稳定的三溴乙醇给药系统至关重要。在本研究中，我们首先采用溶热法合成了两种复合物。然后，我们对传统的生物聚合物 PEG 进行了改性，合成了一种两亲性嵌段共聚物--Cyanine 7-PEG-DDAT，用于包覆 CP1 和装载三溴乙醇（TBE）以进行结构表征。然后，我们对 Cyanine 7-PEG-DDAT-CP1@TBE 进行了生物测试，并比较了其对 C57BL/6 小鼠的麻醉效果与直接注射三溴乙醇的效果。结果为三溴乙醇在小鼠模型和手术中的应用提供了参考。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Molecular Structure 化学-物理化学

CiteScore

7.10

自引率

15.80%

发文量

2384

审稿时长

45 days

期刊介绍： The Journal of Molecular Structure is dedicated to the publication of full-length articles and review papers, providing important new structural information on all types of chemical species including: • Stable and unstable molecules in all types of environments (vapour, molecular beam, liquid, solution, liquid crystal, solid state, matrix-isolated, surface-absorbed etc.) • Chemical intermediates • Molecules in excited states • Biological molecules • Polymers. The methods used may include any combination of spectroscopic and non-spectroscopic techniques, for example: • Infrared spectroscopy (mid, far, near) • Raman spectroscopy and non-linear Raman methods (CARS, etc.) • Electronic absorption spectroscopy • Optical rotatory dispersion and circular dichroism • Fluorescence and phosphorescence techniques • Electron spectroscopies (PES, XPS), EXAFS, etc. • Microwave spectroscopy • Electron diffraction • NMR and ESR spectroscopies • Mössbauer spectroscopy • X-ray crystallography • Charge Density Analyses • Computational Studies (supplementing experimental methods) We encourage publications combining theoretical and experimental approaches. The structural insights gained by the studies should be correlated with the properties, activity and/ or reactivity of the molecule under investigation and the relevance of this molecule and its implications should be discussed.