The positive implication of natural antioxidants on oxidative stress-mediated diabetes mellitus complications

IF 3.5 Q3 Biochemistry, Genetics and Molecular Biology Journal of Genetic Engineering and Biotechnology Pub Date : 2024-09-10 DOI:10.1016/j.jgeb.2024.100424

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Abstract

The complementary intervention to modulate diabetes mellitus (DM) metabolism has recently brought the global attention, since DM has become among the global burden diseases. Where, several related pathways elevate the production of superoxide in consequences. For example, the flux of glycation-derived end products (AGEs) could lead to the deactivation of insulin signaling pathways. In that context, many vitamins and phytochemicals in natural sources have high antioxidant impacts that reduce oxidative stress and cell damages. These chemicals could be applied as bioactive antidiabetic agents. Their mode of actions could be from regulating the intracellular reactive oxygen species (ROS) which cause several pro-inflammatory pathways related to the oxidative stress (OS) and DM. Besides, they have a great potential to control the epigenetic mutations and hyperglycemia and help in back the blood glucose to the normal level. Therefore, the current review addresses the important role of natural functional antioxidants in DM management and its association with its OS complications.

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天然抗氧化剂对氧化应激介导的糖尿病并发症的积极影响

糖尿病（DM）已成为全球负担沉重的疾病之一，因此，通过辅助干预来调节糖尿病（DM）的新陈代谢最近引起了全球的关注。其中，有几种相关途径会导致超氧化物生成增加。例如，糖化衍生终产物（AGEs）的通量会导致胰岛素信号通路失活。在这种情况下，天然来源的许多维生素和植物化学物质具有很强的抗氧化作用，可以减少氧化应激和细胞损伤。这些化学物质可用作生物活性抗糖尿病剂。它们的作用模式可能是调节细胞内的活性氧（ROS），而活性氧会导致与氧化应激（OS）和糖尿病相关的多种促炎途径。此外，它们还具有控制表观遗传突变和高血糖的巨大潜力，有助于将血糖恢复到正常水平。因此，本综述探讨了天然功能性抗氧化剂在 DM 管理中的重要作用及其与 OS 并发症的关联。

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来源期刊

Journal of Genetic Engineering and Biotechnology Biochemistry, Genetics and Molecular Biology-Biotechnology

CiteScore

5.70

自引率

5.70%

发文量

159

审稿时长

16 weeks

期刊介绍： Journal of genetic engineering and biotechnology is devoted to rapid publication of full-length research papers that leads to significant contribution in advancing knowledge in genetic engineering and biotechnology and provide novel perspectives in this research area. JGEB includes all major themes related to genetic engineering and recombinant DNA. The area of interest of JGEB includes but not restricted to: •Plant genetics •Animal genetics •Bacterial enzymes •Agricultural Biotechnology, •Biochemistry, •Biophysics, •Bioinformatics, •Environmental Biotechnology, •Industrial Biotechnology, •Microbial biotechnology, •Medical Biotechnology, •Bioenergy, Biosafety, •Biosecurity, •Bioethics, •GMOS, •Genomic, •Proteomic JGEB accepts