Emerging biomedical technologies for scarless wound healing

IF 18 1区医学 Q1 ENGINEERING, BIOMEDICAL Bioactive Materials Pub Date : 2024-09-11 DOI:10.1016/j.bioactmat.2024.09.001

Xinyue Cao , Xiangyi Wu , Yuanyuan Zhang , Xiaoyun Qian , Weijian Sun , Yuanjin Zhao

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Abstract

Complete wound healing without scar formation has attracted increasing attention, prompting the development of various strategies to address this challenge. In clinical settings, there is a growing preference for emerging biomedical technologies that effectively manage fibrosis following skin injury, as they provide high efficacy, cost-effectiveness, and minimal side effects compared to invasive and costly surgical techniques. This review gives an overview of the latest developments in advanced biomedical technologies for scarless wound management. We first introduce the wound healing process and key mechanisms involved in scar formation. Subsequently, we explore common strategies for wound treatment, including their fabrication methods, superior performance and the latest research developments in this field. We then shift our focus to emerging biomedical technologies for scarless wound healing, detailing the mechanism of action, unique properties, and advanced practical applications of various biomedical technology-based therapies, such as cell therapy, drug therapy, biomaterial therapy, and synergistic therapy. Finally, we critically assess the shortcomings and potential applications of these biomedical technologies and therapeutic methods in the realm of scar treatment.

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用于无疤痕伤口愈合的新兴生物医学技术

没有疤痕形成的伤口完全愈合引起了越来越多的关注，促使人们开发各种策略来应对这一挑战。在临床环境中，人们越来越倾向于采用新兴的生物医学技术来有效处理皮肤损伤后的纤维化，因为与侵入性和昂贵的手术技术相比，这些技术具有疗效高、成本效益高、副作用小等优点。本综述概述了用于无疤痕伤口管理的先进生物医学技术的最新发展。我们首先介绍了伤口愈合过程和疤痕形成的关键机制。随后，我们探讨了常见的伤口处理策略，包括其制造方法、卓越性能以及该领域的最新研究进展。然后，我们将重点转向用于无疤痕伤口愈合的新兴生物医学技术，详细介绍各种基于生物医学技术的疗法（如细胞疗法、药物疗法、生物材料疗法和协同疗法）的作用机制、独特性能和先进的实际应用。最后，我们对这些生物医学技术和治疗方法在疤痕治疗领域的不足之处和潜在应用进行了批判性评估。

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来源期刊

Bioactive Materials Biochemistry, Genetics and Molecular Biology-Biotechnology

CiteScore

28.00

自引率

6.30%

发文量

436

审稿时长

20 days

期刊介绍： Bioactive Materials is a peer-reviewed research publication that focuses on advancements in bioactive materials. The journal accepts research papers, reviews, and rapid communications in the field of next-generation biomaterials that interact with cells, tissues, and organs in various living organisms. The primary goal of Bioactive Materials is to promote the science and engineering of biomaterials that exhibit adaptiveness to the biological environment. These materials are specifically designed to stimulate or direct appropriate cell and tissue responses or regulate interactions with microorganisms. The journal covers a wide range of bioactive materials, including those that are engineered or designed in terms of their physical form (e.g. particulate, fiber), topology (e.g. porosity, surface roughness), or dimensions (ranging from macro to nano-scales). Contributions are sought from the following categories of bioactive materials: Bioactive metals and alloys Bioactive inorganics: ceramics, glasses, and carbon-based materials Bioactive polymers and gels Bioactive materials derived from natural sources Bioactive composites These materials find applications in human and veterinary medicine, such as implants, tissue engineering scaffolds, cell/drug/gene carriers, as well as imaging and sensing devices.