Neuroimaging analysis reveals distinct cerebral perfusion responses to fasting-postprandial metabolic switching in Alzheimer's disease patients

IF 4.8 1区医学 Q1 NEUROSCIENCES CNS Neuroscience & Therapeutics Pub Date : 2024-09-11 DOI:10.1111/cns.70014

Runzhi Li, Zhizheng Zhuo, Zeshan Yao, Zhaohui Li, Yanli Wang, Jiwei Jiang, Linlin Wang, Wenyi Li, Yanling Zhang, Jun Sun, Junjie Li, Yunyun Duan, Yi Liu, Hongyuan Shao, Yang li, Yechuan Zhang, Jinglong Chen, Hanping Shi, Hui Huang, Yaou Liu, Jun Xu

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Abstract

Aims

Extended fasting–postprandial switch intermitting time has been shown to affect Alzheimer's disease (AD). Few studies have investigated the cerebral perfusion response to fasting–postprandial metabolic switching (FMS) in AD patients. We aimed to evaluate the cerebral perfusion response to FMS in AD patients.

Methods

In total, 30 AD patients, 32 mild cognitive impairment (MCI) patients, and 30 healthy control individuals (HCs) were included in the quantification of cerebral perfusion via cerebral blood flow (CBF). The cerebral perfusion response to FMS was defined as the difference (ΔCBF) between fasting and postprandial CBF.

Results

Patients with AD had a regional negative ΔCBF in the anterior temporal lobe, part of the occipital lobe and the parietal lobe under FMS stimulation, whereas HCs had no significant ΔCBF. The AD patients had lower ΔCBF values in the right anterior temporal lobe than the MCI patients and HCs. ΔCBF in the anterior temporal lobe was negatively correlated with cognitive severity and cognitive reserve factors in AD patients.

Conclusions

AD patients exhibited a poor ability to maintain cerebral perfusion homeostasis under FMS stimulation. The anterior temporal lobe is a distinct area that responds to FMS in AD patients and negatively correlates with cognitive function.

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神经成像分析揭示了阿尔茨海默病患者对空腹-餐后代谢转换的不同脑灌注反应

目的延长空腹-餐后代谢转换间歇时间已被证明会影响阿尔茨海默病（AD）。很少有研究调查了AD患者对空腹-餐后代谢转换（FMS）的脑灌注反应。我们旨在评估 AD 患者对 FMS 的脑灌注反应。方法共有30名AD患者、32名轻度认知障碍（MCI）患者和30名健康对照组（HC）参加了通过脑血流（CBF）量化脑灌注的研究。对 FMS 的脑灌注反应定义为空腹和餐后 CBF 之差（ΔCBF）。结果在FMS刺激下，AD患者的颞叶前部、枕叶部分区域和顶叶的ΔCBF呈区域性负值，而HC患者的ΔCBF无明显变化。与 MCI 患者和 HCs 相比，AD 患者右前颞叶的 ΔCBF值较低。颞叶前部的ΔCBF与AD患者的认知严重程度和认知储备因素呈负相关。结论 AD患者在FMS刺激下维持脑灌注平衡的能力较差。前颞叶是AD患者对FMS产生反应的一个独特区域，与认知功能呈负相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

CNS Neuroscience & Therapeutics 医学-神经科学

CiteScore

7.30

自引率

12.70%

发文量

240

审稿时长

2 months

期刊介绍： CNS Neuroscience & Therapeutics provides a medium for rapid publication of original clinical, experimental, and translational research papers, timely reviews and reports of novel findings of therapeutic relevance to the central nervous system, as well as papers related to clinical pharmacology, drug development and novel methodologies for drug evaluation. The journal focuses on neurological and psychiatric diseases such as stroke, Parkinson’s disease, Alzheimer’s disease, depression, schizophrenia, epilepsy, and drug abuse.