Clinico-physiological correlates of Parkinson’s disease from multi-resolution basal ganglia recordings

IF 6.7 1区 医学 Q1 NEUROSCIENCES NPJ Parkinson's Disease Pub Date : 2024-09-12 DOI:10.1038/s41531-024-00773-4
Srdjan Sumarac, Jinyoung Youn, Conor Fearon, Luka Zivkovic, Prerana Keerthi, Oliver Flouty, Milos Popovic, Mojgan Hodaie, Suneil Kalia, Andres Lozano, William Hutchison, Alfonso Fasano, Luka Milosevic
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Abstract

Parkinson’s disease (PD) has been associated with pathological neural activity within the basal ganglia. Herein, we analyzed resting-state single-neuron and local field potential (LFP) activities from people with PD who underwent awake deep brain stimulation surgery of the subthalamic nucleus (STN; n = 125) or globus pallidus internus (GPi; n = 44), and correlated rate-based and oscillatory features with UPDRSIII off-medication subscores. Rate-based single-neuron features did not correlate with PD symptoms. STN single-neuron and LFP low-beta (12–21 Hz) power and burst dynamics showed modest correlations with bradykinesia and rigidity severity, while STN spiketrain theta (4–8 Hz) power correlated modestly with tremor severity. GPi low- and high-beta (21–30 Hz) power and burst dynamics correlated moderately with bradykinesia and axial symptom severity. These findings suggest that elevated single-neuron and LFP oscillations may be linked to symptoms, though modest correlations imply that the pathophysiology of PD may extend beyond resting-state beta oscillations.

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通过多分辨率基底神经节记录了解帕金森病的临床生理学相关性
帕金森病(PD)与基底节内的病理神经活动有关。在此,我们分析了接受清醒深部脑刺激手术的丘脑下核(STN;n = 125)或丘脑内球(GPi;n = 44)帕金森病患者的静息态单神经元和局部场电位(LFP)活动,并将基于速率的特征和振荡特征与UPDRSIII非用药子分数相关联。基于速率的单神经元特征与帕金森病症状无关。STN 单神经元和 LFP 低-beta(12-21 Hz)功率和猝发动态与运动迟缓和僵直严重程度呈适度相关,而 STN spiketrain theta(4-8 Hz)功率与震颤严重程度呈适度相关。GPi 低β和高β(21-30 赫兹)功率和脉冲串动态与运动迟缓和轴性症状严重程度呈中度相关。这些研究结果表明,单神经元和 LFP 振荡的升高可能与症状有关,但适度的相关性意味着帕金森病的病理生理学可能超出了静息态 beta 振荡的范围。
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来源期刊
NPJ Parkinson's Disease
NPJ Parkinson's Disease Medicine-Neurology (clinical)
CiteScore
9.80
自引率
5.70%
发文量
156
审稿时长
11 weeks
期刊介绍: npj Parkinson's Disease is a comprehensive open access journal that covers a wide range of research areas related to Parkinson's disease. It publishes original studies in basic science, translational research, and clinical investigations. The journal is dedicated to advancing our understanding of Parkinson's disease by exploring various aspects such as anatomy, etiology, genetics, cellular and molecular physiology, neurophysiology, epidemiology, and therapeutic development. By providing free and immediate access to the scientific and Parkinson's disease community, npj Parkinson's Disease promotes collaboration and knowledge sharing among researchers and healthcare professionals.
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