Blood profile indicates central inflammation in frontotemporal lobar degeneration

IF 28.2 1区 医学 Q1 CLINICAL NEUROLOGY Nature Reviews Neurology Pub Date : 2024-09-12 DOI:10.1038/s41582-024-01021-2
Ian Fyfe
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血液特征显示额颞叶变性的中枢炎症
新研究发现,促炎性血清特征与额颞叶变性(Frontotemporal lobar degeneration,FLTD)有关,这增加了用血液生物标记物评估痴呆症患者神经炎症的可能性。研究人员分析了214名患有FTLD相关综合征的患者和29名健康人血清中的细胞因子。他们的分析确定了一种与FLTD相关的促炎细胞因子特征。这种血清特征的强烈表达与更严重的中枢神经炎症(PET 成像显示小胶质细胞活化)和更短的存活期有关。
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来源期刊
Nature Reviews Neurology
Nature Reviews Neurology 医学-临床神经学
CiteScore
29.90
自引率
0.80%
发文量
138
审稿时长
6-12 weeks
期刊介绍: Nature Reviews Neurology aims to be the premier source of reviews and commentaries for the scientific and clinical communities we serve. We want to provide an unparalleled service to authors, referees, and readers, and we work hard to maximize the usefulness and impact of each article. The journal publishes Research Highlights, Comments, News & Views, Reviews, Consensus Statements, and Perspectives relevant to researchers and clinicians working in the field of neurology. Our broad scope ensures that the work we publish reaches the widest possible audience. Our articles are authoritative, accessible, and enhanced with clearly understandable figures, tables, and other display items. This page gives more detail about the aims and scope of the journal.
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