Combining cerebrospinal fluid and PI-2620 tau-PET for biomarker-based stratification of Alzheimer's disease and 4R-tauopathies

IF 13 1区 医学 Q1 CLINICAL NEUROLOGY Alzheimer's & Dementia Pub Date : 2024-09-12 DOI:10.1002/alz.14185
Roxane Dilcher, Stephan Wall, Mattes Groß, Sabrina Katzdobler, Olivia Wagemann, Carla Palleis, Endy Weidinger, Urban Fietzek, Alexander Bernhardt, Carolin Kurz, Christian Ferschmann, Maximilian Scheifele, Mirlind Zaganjori, Johannes Gnörich, Katharina Bürger, Daniel Janowitz, Boris-Stephan Rauchmann, Sophia Stöcklein, Peter Bartenstein, Victor Villemagne, John Seibyl, Osama Sabri, Henryk Barthel, Robert Perneczky, Florian Schöberl, Andreas Zwergal, Günter U. Höglinger, Johannes Levin, Nicolai Franzmeier, Matthias Brendel
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引用次数: 0

Abstract

Recent advances in biomarker research have improved the diagnosis and monitoring of Alzheimer's disease (AD), but in vivo biomarker-based workflows to assess 4R-tauopathy (4RT) patients are currently missing. We suggest a novel biomarker-based algorithm to characterize AD and 4RTs.
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结合脑脊液和 PI-2620 tau-PET 对阿尔茨海默病和 4R-tauopathies 进行生物标记分层
生物标志物研究的最新进展改善了阿尔茨海默病(AD)的诊断和监测,但目前还缺少基于生物标志物的体内工作流程来评估 4R 陶病(4RT)患者。我们提出了一种基于生物标志物的新算法来描述阿尔茨海默病和 4RT 的特征。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Alzheimer's & Dementia
Alzheimer's & Dementia 医学-临床神经学
CiteScore
14.50
自引率
5.00%
发文量
299
审稿时长
3 months
期刊介绍: Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.
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