Sleep-dependent memory consolidation in young and aged brains

IF 1.7 Q3 CLINICAL NEUROLOGY Aging brain Pub Date : 2024-01-01 DOI:10.1016/j.nbas.2024.100124
Deependra Kumar, Masashi Yanagisawa, Hiromasa Funato
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Abstract

Young children and aged individuals are more prone to memory loss than young adults. One probable reason is insufficient sleep-dependent memory consolidation. Sleep timing and sleep-stage duration differ between children and aged individuals compared to adults. Frequent daytime napping and fragmented sleep architecture are common in children and older individuals. Moreover, sleep-dependent oscillations that play crucial roles in long-term memory storage differ among age groups. Notably, the frontal cortex, which is important for long-term memory storage undergoes major structural changes in children and aged subjects. The similarities in sleep dynamics between children and aged subjects suggest that a deficit in sleep-dependent consolidation contributes to memory loss in both age groups.

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年轻人和老年人大脑中依赖睡眠的记忆巩固
幼儿和老年人比青壮年更容易丧失记忆力。其中一个可能的原因是依赖睡眠的记忆巩固不足。儿童和老年人的睡眠时间和睡眠阶段持续时间与成年人不同。儿童和老年人白天频繁打盹和睡眠结构碎片化的现象很常见。此外,在长期记忆存储过程中起关键作用的睡眠依赖性振荡在不同年龄组之间也存在差异。值得注意的是,对长期记忆存储起重要作用的额叶皮层在儿童和老年人身上发生了重大结构变化。儿童和老年受试者睡眠动态的相似性表明,睡眠依赖性巩固的缺失导致了这两个年龄组的记忆丧失。
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Aging brain
Aging brain Neuroscience (General), Geriatrics and Gerontology
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