Neuregulin-1 immunoreactivity in peripheral plasma is associated with rs6982890 polymorphism-mediated psychotic symptoms in schizophrenia

IF 3.5 3区 医学 Q2 NEUROSCIENCES Brain Research Bulletin Pub Date : 2024-09-08 DOI:10.1016/j.brainresbull.2024.111075
Xiujuan Wang , Jiahui Zhou , Shuang Ding , Jianhong Zhang , Yiliang Liu , Ya Liu , Jingyuan Zhao , Han Shi , Qing Liu , Meng Song , Luxian Lv , Wenqiang Li , Yongfeng Yang
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Abstract

Objectives

Neuregulin 1 (NRG1) is a risk gene for schizophrenia and involved in neurodevelopment and synaptic plasticity. Polymorphisms in NRG1 may affect psychotic symptoms in schizophrenia. This study investigated the effects of the single nucleotide polymorphism (SNP) rs6982890 on peripheral plasma NRG1 immunoreactivity, clinical symptoms and cognitive functions in schizophrenia patients.

Material and methods

We recruited subjects from the Han population of northern China from 2010 to 2022. We first genotyped and analyzed 6 NRG1 SNPS in 1304 patients with schizophrenia and 871 healthy controls. Then, 91 patients with schizophrenia and 40 healthy controls were selected to detect the peripheral plasma NRG1 immunoreactivity by ELISA. Among them, 84 patients were divided into rs6982890 genotypes to analyze the correlation between NRG1 immunoreactivity and clinical symptoms.

Results

Rs6982890 allelic frequencies were statistically significant between patients and controls. Baseline peripheral plasma NRG1 immunoreactivity in patients were significantly lower than controls. NRG1 immunoreactivity in patients were significantly increased after 8 weeks of antipsychotic treatment and significantly correlated with clinical symptoms and cognitive function. Genotyping of patients with SNP rs6982890 indicated NRG1 immunoreactivity in CC genotype increased significantly after treatment, while CT genotype had no significant change. Baseline NRG1 immunoreactivity with the CT genotype were significantly higher than CC genotype.

Conclusions

NRG1 SNP rs6982890 is significantly associated with schizophrenia in the Han population of northern China, and it may affect the effect of antipsychotic drug treatment by regulating the peripheral plasma NRG1 immunoreactivity.

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外周血浆中的神经胶质蛋白-1免疫活性与rs6982890多态性介导的精神分裂症精神病性症状有关
目的神经胶质蛋白 1(NRG1)是精神分裂症的风险基因,参与神经发育和突触可塑性。NRG1 的多态性可能会影响精神分裂症患者的精神症状。本研究探讨了单核苷酸多态性(SNP)rs6982890对精神分裂症患者外周血浆NRG1免疫活性、临床症状和认知功能的影响。我们首先对1304名精神分裂症患者和871名健康对照者的6个NRG1 SNPS进行了基因分型和分析。然后,我们选取了91名精神分裂症患者和40名健康对照者,用ELISA方法检测外周血浆NRG1免疫反应。其中,84名患者被分为rs6982890基因型,以分析NRG1免疫反应与临床症状之间的相关性。患者的基线外周血浆 NRG1 免疫活性明显低于对照组。抗精神病药物治疗8周后,患者的NRG1免疫活性明显升高,并与临床症状和认知功能明显相关。对患者进行的 SNP rs6982890 基因分型显示,CC 基因型患者的 NRG1 免疫反应性在治疗后明显增加,而 CT 基因型则无明显变化。结论在中国北方汉族人群中,NRG1 SNP rs6982890与精神分裂症显著相关,它可能通过调节外周血浆NRG1免疫反应影响抗精神病药物的治疗效果。
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来源期刊
Brain Research Bulletin
Brain Research Bulletin 医学-神经科学
CiteScore
6.90
自引率
2.60%
发文量
253
审稿时长
67 days
期刊介绍: The Brain Research Bulletin (BRB) aims to publish novel work that advances our knowledge of molecular and cellular mechanisms that underlie neural network properties associated with behavior, cognition and other brain functions during neurodevelopment and in the adult. Although clinical research is out of the Journal''s scope, the BRB also aims to publish translation research that provides insight into biological mechanisms and processes associated with neurodegeneration mechanisms, neurological diseases and neuropsychiatric disorders. The Journal is especially interested in research using novel methodologies, such as optogenetics, multielectrode array recordings and life imaging in wild-type and genetically-modified animal models, with the goal to advance our understanding of how neurons, glia and networks function in vivo.
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