Increasing trends of non-tuberculous mycobacteria clinical isolates in Guangzhou, China

IF 2.1 3区 医学 Q2 PARASITOLOGY Acta tropica Pub Date : 2024-09-10 DOI:10.1016/j.actatropica.2024.107398
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Abstract

Non-tuberculous mycobacteria (NTM) are one of major public health concern. The current study aimed to find the prevalence trends of NTM in Guangzhou, China from January 2018 to December 2023. A total of 26,716 positive mycobacterial cultures were collected. Thirty-six specimens with incomplete personal information were excluded. The remaining 26,680 specimens were identified using a gene chip method. 16,709 isolates were Mycobacterium tuberculosis (MTB) (62.63 %), and 9,971 were NTM (37.37 %). 43.43 % (4,330/9,971) of NTM isolates were male, and 56.57 % (5,641/9,971) were female (χ2 = 24.36, P < 0.05), a male to female ratio of approximately 1:1.30. Infections in individuals with aged 40 years and above was higher (77.63 %) than below 40 years (22.37 %) (χ2 = 4.94, P = 0.026). The annual NTM isolation rates from 2018 to 2023 were 32.03 %, 34.00 %, 36.27 %, 38.58 %, 38.99 %, and 43.24 %, respectively, showing an increasing trend (χ2 for trend = 0.097, P < 0.05) (R = 0.097, P < 0.05). Out of 9,971 NTM isolates, 8,881 cases include only five common NTM species (MAC, M. abscessus/M. chelonae, M. kansasii, M. fortuitum, and M. gordonae). The overall NTM isolation rate was 37.37 %. The NTM isolation rate was significantly higher than the national average, showing an increasing trend over the last six years.

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中国广州非结核分枝杆菌临床分离株的增加趋势
非结核分枝杆菌(NTM)是主要的公共卫生问题之一。本研究旨在了解 2018 年 1 月至 2023 年 12 月期间中国广州市非结核分枝杆菌的流行趋势。研究共收集了 26716 份阳性分枝杆菌培养物。排除了36份个人信息不完整的标本。其余 26,680 份标本采用基因芯片方法进行鉴定。分离出的 16 709 份样本为结核分枝杆菌(MTB)(62.63%),9 971 份样本为非结核分枝杆菌(NTM)(37.37%)。43.43%(4330/9971 例)的 NTM 分离物为男性,56.57%(5641/9971 例)为女性(χ2 = 24.36,P < 0.05),男女比例约为 1:1.30。40 岁及以上人群的感染率(77.63%)高于 40 岁以下人群(22.37%)(χ2 = 4.94,P = 0.026)。2018年至2023年每年的NTM分离率分别为32.03 %、34.00 %、36.27 %、38.58 %、38.99 %和43.24 %,呈上升趋势(趋势χ2 = 0.097,P <0.05)(R = 0.097,P <0.05)。在 9,971 例 NTM 分离物中,8,881 例只包括五种常见的 NTM 物种(MAC、脓毒症 M./M.chelonae、堪萨斯 M.、M.fortuitum 和 M.gordonae)。总的 NTM 分离率为 37.37%。NTM分离率明显高于全国平均水平,在过去六年中呈上升趋势。
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来源期刊
Acta tropica
Acta tropica 医学-寄生虫学
CiteScore
5.40
自引率
11.10%
发文量
383
审稿时长
37 days
期刊介绍: Acta Tropica, is an international journal on infectious diseases that covers public health sciences and biomedical research with particular emphasis on topics relevant to human and animal health in the tropics and the subtropics.
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