Synthesis and biomedical potential of silk fiber/methylcellulose composite containing copper and zinc co-substituted hydroxyapatite for bone tissue engineering applications
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引用次数: 0
Abstract
The primary feature of biomaterials is to aid in the regeneration of damaged tissues and organs. To attain a biomaterial, we fabricated a double mineral (copper and zinc) substituted hydroxyapatite/silk fiber/methylcellulose (CZ-HAP/SF/MC) nanocomposite by the E-Spin method. The as-developed CZ-HAP/SF/MC nanocomposite was characterized by Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD) and moreover, the fabricated nanocomposites were used to investigate morphological changes, porosity, swelling test, mechanical strength, antibacterial activity and apatite growth. In addition, antimicrobial studies demonstrated that CZ-HAP/SF/MC nanocomposite exhibited excellent antimicrobial activity against S. aureus, E. coli and C. albicans and, the resultant nanocomposite revealed that the CZ-HAP/SF/MC nanocomposite will be an effective implant material for better cell growth in BTE applications.
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