Retrospective analysis of Sliding Scale versus Basal Bolus Insulin in the treatment of uncontrolled hyperglycemia in patients with Type 2 diabetes mellitus and infections

IF 0.7 4区医学 Q4 ENDOCRINOLOGY & METABOLISM International Journal of Diabetes in Developing Countries Pub Date : 2024-09-12 DOI:10.1007/s13410-024-01397-3

Sanjeevani M., Megha Alex, Devika P. Sreedharan, Vinay B. C., Supriya P. S., Ramesh Bhandari, Reshma Kolar

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Abstract

Background

Basal Bolus Insulin (BBI) and Sliding Scale Insulin (SSI) regimens are the two choices for managing uncontrolled hyperglycemia in patients with Type 2 diabetes mellitus (T2DM).

Objective

We aimed to compare the glycemic control achieved and the duration of infection recovery in hospitalized Type 2 Diabetic patients with infections treated with SSI and BBI regimens.

Methods

A retrospective comparative study was performed for 6 months; a total of 126 patients were divided into 2 groups, the SSI group (n = 63) and the BBI group (n = 63). Fasting Blood Glucose (FBG) levels and duration of antibiotic therapy during hospitalization were used to assess glycemic control and infection recovery duration, respectively.

Results

On the first day, the mean FBG values were 244.75 ± 81.72 in the BBI group and 191.21 ± 90.45 in the SSI group. On the last day, these values decreased to 159.40 ± 79.31 in the BBI group and 167.21 ± 61.81 in the SSI group. The statistical analysis revealed a significant improvement in glycemic control within the BBI group (p < 0.001), while in the SSI group, a statistically significant improvement in glycemic control was not achieved (p = 0.106).

Conclusion

Better glycemic control was seen in the BBI group and overall infection recovery duration was lesser in the SSI group than BBI group.

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在治疗 2 型糖尿病和感染患者不受控制的高血糖时使用滑动量表法和基础注射法胰岛素的回顾性分析

背景基础胰岛素（BBI）和滑动胰岛素（SSI）方案是治疗 2 型糖尿病（T2DM）患者血糖失控的两种选择。方法进行了一项为期 6 个月的回顾性比较研究，将 126 名患者分为两组，即 SSI 组（63 人）和 BBI 组（63 人）。结果第一天，BBI 组的平均 FBG 值为 244.75 ± 81.72，SSI 组为 191.21 ± 90.45。最后一天，BBI 组的平均 FBG 值降至 159.40 ± 79.31，SSI 组降至 167.21 ± 61.81。统计分析显示，BBI 组的血糖控制有明显改善（p <0.001），而 SSI 组的血糖控制没有明显改善（p = 0.106）。

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来源期刊

International Journal of Diabetes in Developing Countries ENDOCRINOLOGY & METABOLISM-

CiteScore

1.60

自引率

0.00%

发文量

109

审稿时长

6 months

期刊介绍： International Journal of Diabetes in Developing Countries is the official journal of Research Society for the Study of Diabetes in India. This is a peer reviewed journal and targets a readership consisting of clinicians, research workers, paramedical personnel, nutritionists and health care personnel working in the field of diabetes. Original research articles focusing on clinical and patient care issues including newer therapies and technologies as well as basic science issues in this field are considered for publication in the journal. Systematic reviews of interest to the above group of readers are also accepted.