T. Togtokhtur, E. B. Dushanov, T. A. Kulahava, M. Batmunkh, A. N. Bugay
{"title":"Calculation of DNA Damage in the Tumor Cell on Boron Neutron Capture Therapy","authors":"T. Togtokhtur, E. B. Dushanov, T. A. Kulahava, M. Batmunkh, A. N. Bugay","doi":"10.1134/s1547477124701425","DOIUrl":null,"url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Abstract</h3><p>The boron neutron capture therapy technique has been appealing to advance the technical and medical development of aspects of malignant tumors. The concept of the method has been aimed at dose contribution by secondary particles for targeted tumor sites while neutron beams do not have enough radiation effects to damage healthy cells with an advantage. This study focused on calculating the dose deposition of secondary particles from nuclear reactions between various mono-energetic neutrons and <sup>10</sup>B with different concentrations. In this simulation, we carried out the single-cell model of human glial tumors with several potential distributions of boron nanoparticles as L-BPA. The resulting absorbed boron dose was more significant than the dose from other particles on the lower part of epithermal neutron energy ranges when higher boron concentration. Accordingly, we estimated the DNA damage in the cell geometry with the sphere and ellipsoid caused by the secondary particles using the GEANT4-DNA toolkit, respectively. The findings highlight the importance of precise dose calculations of high LET particles and considering secondary particle effects when evaluating the efficacy of BNCT in tumor treatment.</p>","PeriodicalId":730,"journal":{"name":"Physics of Particles and Nuclei Letters","volume":"11 1","pages":""},"PeriodicalIF":0.4000,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Physics of Particles and Nuclei Letters","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1134/s1547477124701425","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"PHYSICS, PARTICLES & FIELDS","Score":null,"Total":0}
引用次数: 0
Abstract
The boron neutron capture therapy technique has been appealing to advance the technical and medical development of aspects of malignant tumors. The concept of the method has been aimed at dose contribution by secondary particles for targeted tumor sites while neutron beams do not have enough radiation effects to damage healthy cells with an advantage. This study focused on calculating the dose deposition of secondary particles from nuclear reactions between various mono-energetic neutrons and 10B with different concentrations. In this simulation, we carried out the single-cell model of human glial tumors with several potential distributions of boron nanoparticles as L-BPA. The resulting absorbed boron dose was more significant than the dose from other particles on the lower part of epithermal neutron energy ranges when higher boron concentration. Accordingly, we estimated the DNA damage in the cell geometry with the sphere and ellipsoid caused by the secondary particles using the GEANT4-DNA toolkit, respectively. The findings highlight the importance of precise dose calculations of high LET particles and considering secondary particle effects when evaluating the efficacy of BNCT in tumor treatment.
期刊介绍：
The journal Physics of Particles and Nuclei Letters, brief name Particles and Nuclei Letters, publishes the articles with results of the original theoretical, experimental, scientific-technical, methodological and applied research. Subject matter of articles covers: theoretical physics, elementary particle physics, relativistic nuclear physics, nuclear physics and related problems in other branches of physics, neutron physics, condensed matter physics, physics and engineering at low temperatures, physics and engineering of accelerators, physical experimental instruments and methods, physical computation experiments, applied research in these branches of physics and radiology, ecology and nuclear medicine.
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