Potential and Limitation of Peptides from Native Plants of Uttarakhand

IF 2 4区 生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY International Journal of Peptide Research and Therapeutics Pub Date : 2024-09-03 DOI:10.1007/s10989-024-10634-6
Neha Kamboj, Rahul Kumar, Navin Kumar, Pankaj Gautam
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Abstract

Knowledge of plant-based medicines in the Uttarakhand region is extensive, and these remedies are utilized for preventive and curative purposes. Traditional medical knowledge and herbal remedies form the backbone of primary health care system. The native plants in Uttarakhand are essential to the local tribes because they can produce food and medicine. Examples include Buransh (Rhododendron) flowers, Sal (Shorea robusta), Chora (Angelica glauca), Timuru (Zanthoxylum armatum), Jatamansi (Nardostachys), Kutki (Picrorhiza kurroa), Brahma Kamal (Saussurea obvallata). The diverse range of plants in this area may be explored for antimicrobial peptides (AMPs) or proteins that can serve as alternative treatments to combat resistant Gram-positive and Gram-negative bacteria effectively. Given the ever-increasing drug resistance among clinical pathogens, the value of novel AMPs is particularly relevant. In plants, the distinguishing feature of antimicrobial peptides (AMPs) lies in the plentiful occurrence of cysteine residues, which contribute to the formation of numerous disulfide bonds. Several plant AMP families exist as defensins, hairpin-like peptides, thionins, knottin-type peptides (cyclic and linear), snakins, α-hairpins, and lipid transfer proteins. Some plants AMPs possess high levels of amino acids other than cysteine. Plant AMPs have the unique capability to cluster into distinct families and share conserved structural folds. Over time, computational approaches have gained prominence in understanding the crucial facets of antimicrobial peptides (AMPs). These approaches offer the advantage of reducing the time and expense associated with traditional wet lab experiments. Several databases and tools have been created to aid researchers in providing up-to-date details on AMPs. However, despite the growing possibility of AMP resources in biological repositories, locating plant-derived AMPs remains challenging.

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北阿坎德邦本土植物肽的潜力和局限性
北阿坎德邦的植物药知识非常丰富,这些药方被用于预防和治疗目的。传统医学知识和草药疗法是初级保健系统的支柱。北阿坎德邦的本地植物对当地部落至关重要,因为它们可以生产食物和药物。例如,布兰什(Rhododendron)花、萨尔(Shorea robusta)、乔拉(Angelica glauca)、蒂穆鲁(Zanthoxylum armatum)、Jatamansi(Nardostachys)、库特基(Picrorhiza kurroa)、梵天卡玛尔(Saussurea obvallata)。该领域的植物种类繁多,可开发抗菌肽(AMPs)或蛋白质,作为替代疗法有效对抗耐药性革兰氏阳性和革兰氏阴性细菌。鉴于临床病原体的耐药性不断增加,新型 AMPs 的价值尤为重要。在植物中,抗菌肽(AMPs)的显著特点在于含有大量半胱氨酸残基,有助于形成大量二硫键。一些植物抗菌肽家族包括防御素、发夹样肽、硫肽、节肽(环状和线状)、蛇肽、α-发夹肽和脂质转移蛋白。除半胱氨酸外,一些植物 AMP 还含有大量其他氨基酸。植物 AMPs 具有独特的聚类能力,可组成不同的家族,并共享保守的结构褶皱。随着时间的推移,计算方法在了解抗菌肽(AMPs)的关键方面已变得越来越重要。这些方法具有减少传统湿实验室实验所需时间和费用的优势。为了帮助研究人员提供有关 AMPs 的最新详细信息,人们创建了一些数据库和工具。然而,尽管生物库中的 AMP 资源越来越多,但要找到植物源 AMPs 仍然具有挑战性。
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来源期刊
CiteScore
5.50
自引率
8.00%
发文量
131
审稿时长
>12 weeks
期刊介绍: The International Journal for Peptide Research & Therapeutics is an international, peer-reviewed journal focusing on issues, research, and integration of knowledge on the latest developments in peptide therapeutics. The Journal brings together in a single source the most exciting work in peptide research, including isolation, structural characterization, synthesis and biological activity of peptides, and thereby aids in the development of unifying concepts from diverse perspectives. The Journal invites substantial contributions in the following thematic areas: -New advances in peptide drug delivery systems. -Application of peptide therapeutics to specific diseases. -New advances in synthetic methods. -The development of new procedures for construction of peptide libraries and methodology for screening of such mixtures. -The use of peptides in the study of enzyme specificity and mechanism, receptor binding and antibody/antigen interactions -Applications of such techniques as chromatography, electrophoresis, NMR and X-ray crystallography, mass spectrometry.
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