Roberto Bernasconi, Anna Nova, Buse Aktas, Salvador Pané, Luca Magagnin
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引用次数: 0
Abstract
Microrobotic swarms, with their intrinsic ability to multiply the properties of a single device by hundreds or thousands of times, demonstrate great potential for advanced microsurgery, targeted drug delivery or manipulation at the microscale. This is especially true in the case of magnetically actuated swarms, which can be remotely manipulated with high precision also in-vivo. The manufacturing and the collective actuation of a large number of devices, however, is a challenging task and it requires the development of highly tailored, adaptable and low cost strategies. In the present work, we demonstrate that a combination of inkjet assisted lithography (IAL) and electroforming can be a high-throughput, scalable and low-cost fabrication method for the production of disk-shaped ferromagnetic micromotors. Thanks to the versatility of the hybrid manufacturing technique developed, the diameter and the thickness of the devices can be easily controlled and tailored according to the target application. In addition, the use of electroforming makes possible the manufacturing of soft or hard magnetic devices, whose magnetization direction can be programmed. In the specific case, Ni and CoNiP devices were produced, characterized and actuated in swarms composed of hundreds of individuals. According to their magnetic properties, the devices exhibited highly controllable actuation patterns with multiple degrees of freedom. In order to provide an applicative perspective, the ferromagnetic micromotors were coated with polypyrrole and employed for drug delivery, evidencing thus their capability to load and release the model molecule Rhodamine B.
微型机器人群具有将单个设备的性能提高数百或数千倍的内在能力,在先进的显微外科手术、靶向药物输送或微观操作方面具有巨大潜力。尤其是磁驱动蜂群,可以在体内进行高精度的远程操控。然而,制造和集体驱动大量设备是一项具有挑战性的任务,需要开发高度定制、适应性强和低成本的策略。在本研究中,我们证明了喷墨辅助光刻(IAL)和电铸相结合是一种高通量、可扩展和低成本的制造方法,可用于生产盘状铁磁微电机。由于所开发的混合制造技术具有多功能性,因此可以根据目标应用轻松控制和定制器件的直径和厚度。此外,利用电铸技术还可以制造磁化方向可编程的软磁或硬磁器件。在这个具体案例中,镍和钴镍珀器件被生产出来,并在由数百个个体组成的群中进行表征和驱动。根据其磁性能,这些装置表现出高度可控的多自由度致动模式。为了提供一个应用角度,铁磁微电机涂覆了聚吡咯,并被用于药物输送,从而证明了它们装载和释放模型分子罗丹明 B 的能力。
期刊介绍:
Journal Name: Applied Materials Today
Focus:
Multi-disciplinary, rapid-publication journal
Focused on cutting-edge applications of novel materials
Overview:
New materials discoveries have led to exciting fundamental breakthroughs.
Materials research is now moving towards the translation of these scientific properties and principles.