Research Hotspots in Mitochondria-Related Studies for AKI Treatment: A Bibliometric Study

IF 4.7 2区医学 Q1 CHEMISTRY, MEDICINAL Drug Design, Development and Therapy Pub Date : 2024-09-11 DOI:10.2147/dddt.s473426

Mengfan Yang, Youqun Huang, Anqi Tang, Yu Zhang, Yu Liu, Zhenliang Fan, Mingquan Li

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Abstract

Purpose: Acute kidney injury (AKI) is a common clinical critical condition that has become a significant healthcare burden. In recent years, the relationship between AKI and mitochondria has attracted increasing attention. Protecting mitochondria or restoring their function has emerged as a novel therapeutic strategy for alleviating AKI. This study aims to analyze and summarize the current status, research trends, and hotspots in this field, providing references and directions for future research.
Methods: AKI and mitochondria-related literature from the Web of Science core collection were retrieved and collected. Bibliometric and visualization analyses were conducted using Microsoft Excel 2021, bibliometric tools (VosViewer, Citespace 6.3.R1, and the bibliometrix R package), R 4.3.2, and SCImagoGraphica software.
Results: A total of 2433 publications were included in this study. The number of annual publications in this field has increased year by year. China and the United States are the two most productive countries. Central South University is the most influential research institution in terms of research output, and Parikh SM, Schnellmann RG, and Dong Z are the most influential authors in this field. KIDNEY INTERNATIONAL, JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, and AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY are the most influential journals. Initially, the research focused on keywords such as oxidative stress, ischemia-reperfusion injury, apoptosis, inflammation, and autophagy. In recent years, new research hotspots have emerged, including ferroptosis, aging, mitochondrial quality control, messenger RNA, mitochondrial-targeted antioxidants, extracellular vesicles, and nanodrug delivery.
Conclusion: Research on the relationship between mitochondria and AKI has broad developing prospects, and targeting mitochondrial regulation will become a focus of future AKI prevention and treatment research.

Keywords: acute kidney injury, mitochondria, bibliometric analysis, visualization, VOSviewer, citespace

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治疗 AKI 的线粒体相关研究热点：文献计量学研究

目的：急性肾损伤（AKI）是一种常见的临床危重症，已成为医疗保健的重要负担。近年来，急性肾损伤与线粒体之间的关系引起了越来越多的关注。保护线粒体或恢复其功能已成为缓解 AKI 的一种新型治疗策略。本研究旨在分析和总结该领域的研究现状、研究趋势和热点，为未来研究提供参考和方向：方法：检索并收集了 Web of Science 核心数据库中与 AKI 和线粒体相关的文献。使用 Microsoft Excel 2021、文献计量工具（VosViewer、Citespace 6.3.R1 和 bibliometrix R 软件包）、R 4.3.2 和 SCImagoGraphica 软件进行文献计量和可视化分析：本研究共收录了 2433 篇出版物。该领域的年度出版物数量逐年增加。中国和美国是发表论文最多的两个国家。就研究成果而言，中南大学是最有影响力的研究机构，Parikh SM、Schnellmann RG 和 Dong Z 是该领域最有影响力的作者。KIDNEY INTERNATIONAL》、《JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY》和《American JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY》是最有影响力的期刊。最初的研究主要集中在氧化应激、缺血再灌注损伤、细胞凋亡、炎症和自噬等关键词上。近年来，新的研究热点不断涌现，包括铁变态反应、衰老、线粒体质量控制、信使 RNA、线粒体靶向抗氧化剂、细胞外囊泡和纳米药物递送等：线粒体与 AKI 关系的研究具有广阔的发展前景，针对线粒体的调控将成为未来 AKI 预防和治疗研究的重点。

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来源期刊

Drug Design, Development and Therapy CHEMISTRY, MEDICINAL-PHARMACOLOGY & PHARMACY

CiteScore

9.00

自引率

0.00%

发文量

382

审稿时长

>12 weeks

期刊介绍： Drug Design, Development and Therapy is an international, peer-reviewed, open access journal that spans the spectrum of drug design, discovery and development through to clinical applications. The journal is characterized by the rapid reporting of high-quality original research, reviews, expert opinions, commentary and clinical studies in all therapeutic areas. Specific topics covered by the journal include: Drug target identification and validation Phenotypic screening and target deconvolution Biochemical analyses of drug targets and their pathways New methods or relevant applications in molecular/drug design and computer-aided drug discovery* Design, synthesis, and biological evaluation of novel biologically active compounds (including diagnostics or chemical probes) Structural or molecular biological studies elucidating molecular recognition processes Fragment-based drug discovery Pharmaceutical/red biotechnology Isolation, structural characterization, (bio)synthesis, bioengineering and pharmacological evaluation of natural products** Distribution, pharmacokinetics and metabolic transformations of drugs or biologically active compounds in drug development Drug delivery and formulation (design and characterization of dosage forms, release mechanisms and in vivo testing) Preclinical development studies Translational animal models Mechanisms of action and signalling pathways Toxicology Gene therapy, cell therapy and immunotherapy Personalized medicine and pharmacogenomics Clinical drug evaluation Patient safety and sustained use of medicines.