A nuclear hormone receptor nhr-76 programs age-dependent chemotaxis decline in C. elegans

Rikuou Yokosaka, Kentaro Noma
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Abstract

A decline in food-searching behavior of post-reproductive animals can be beneficial for the population and possibly programmed by the genome. We investigated the genetic program of age-dependent decline in chemotaxis behavior toward an odorant secreted from bacterial food in C. elegans. Through a forward genetic screen, we identified a nuclear hormone receptor, nhr-76, whose mutants ameliorate the age-dependent chemotaxis decline. We found that nhr-76 downregulates the expression of the odorant receptor during aging. Because NHR-76 expression and localization did not change during aging, secretion of its hydrophobic ligands might alter the activity of NHR-76 to cause age-dependent chemotaxis decline. Our findings imply that post-reproductive behavioral decline can be genetically programmed.
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核荷尔蒙受体 nhr-76 可控制 elegans 年龄依赖性趋化性的衰退
繁殖后动物寻找食物行为的下降可能对种群有益,也可能是基因组编程的结果。我们研究了草履虫对细菌食物分泌的气味的趋化行为随年龄下降的遗传程序。通过正向遗传筛选,我们发现了一种核激素受体--nhr-76,其突变体可改善年龄依赖性趋化性下降。我们发现,在衰老过程中,nhr-76会下调气味受体的表达。由于NHR-76的表达和定位在衰老过程中没有变化,其疏水配体的分泌可能会改变NHR-76的活性,从而导致年龄依赖性趋化性下降。我们的研究结果表明,繁殖后行为的衰退可以通过基因编程实现。
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