{"title":"Bifidobacterium longum subsp. infantis YLGB‐1496—Toxicological evaluation","authors":"Jian Zhao, Yueyi Guo, Qiuyue Jiang, Hanglian Lan, Wei‐Lian Hung, Barry Lynch","doi":"10.1002/jat.4688","DOIUrl":null,"url":null,"abstract":"<jats:styled-content style=\"fixed-case\"><jats:italic>Bifidobacterium infantis</jats:italic></jats:styled-content> YLGB‐1496, originally isolated from breast milk from a Taiwanese mother, is under study for use as a probiotic. As part of safety assessment, an Ames, in vivo mouse micronucleus, and in vivo mouse spermatocyte chromosome aberration assay were conducted along with a 13‐week oral rat toxicity study. <jats:styled-content style=\"fixed-case\"><jats:italic>B. infantis</jats:italic></jats:styled-content> YLGB‐1496 had no activity in any of the genotoxicity assays. Administration of the bacteria to Sprague–Dawley rats at doses ranging from 0 to 1.5 g/kg bw/day had no treatment‐related effects on any of the endpoints measured. There appear to be no concerns for translocation or pathogenicity of <jats:styled-content style=\"fixed-case\"><jats:italic>B. infantis</jats:italic></jats:styled-content> YLGB‐1496 based on extensive experience with the species in general. The results of the current investigations support potential use of <jats:styled-content style=\"fixed-case\"><jats:italic>B. infantis</jats:italic></jats:styled-content> YLGB‐1496 as a probiotic in infant formula.","PeriodicalId":15242,"journal":{"name":"Journal of Applied Toxicology","volume":"4 1","pages":""},"PeriodicalIF":2.7000,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Applied Toxicology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/jat.4688","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"TOXICOLOGY","Score":null,"Total":0}
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Abstract
Bifidobacterium infantis YLGB‐1496, originally isolated from breast milk from a Taiwanese mother, is under study for use as a probiotic. As part of safety assessment, an Ames, in vivo mouse micronucleus, and in vivo mouse spermatocyte chromosome aberration assay were conducted along with a 13‐week oral rat toxicity study. B. infantis YLGB‐1496 had no activity in any of the genotoxicity assays. Administration of the bacteria to Sprague–Dawley rats at doses ranging from 0 to 1.5 g/kg bw/day had no treatment‐related effects on any of the endpoints measured. There appear to be no concerns for translocation or pathogenicity of B. infantis YLGB‐1496 based on extensive experience with the species in general. The results of the current investigations support potential use of B. infantis YLGB‐1496 as a probiotic in infant formula.
期刊介绍：
Journal of Applied Toxicology publishes peer-reviewed original reviews and hypothesis-driven research articles on mechanistic, fundamental and applied research relating to the toxicity of drugs and chemicals at the molecular, cellular, tissue, target organ and whole body level in vivo (by all relevant routes of exposure) and in vitro / ex vivo. All aspects of toxicology are covered (including but not limited to nanotoxicology, genomics and proteomics, teratogenesis, carcinogenesis, mutagenesis, reproductive and endocrine toxicology, toxicopathology, target organ toxicity, systems toxicity (eg immunotoxicity), neurobehavioral toxicology, mechanistic studies, biochemical and molecular toxicology, novel biomarkers, pharmacokinetics/PBPK, risk assessment and environmental health studies) and emphasis is given to papers of clear application to human health, and/or advance mechanistic understanding and/or provide significant contributions and impact to their field.
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