Is there a prodrome to NMOSD? An investigation of neurologic symptoms preceding the first NMOSD attack.

IF 4.8 2区 医学 Q1 CLINICAL NEUROLOGY Multiple Sclerosis Journal Pub Date : 2024-09-11 DOI:10.1177/13524585241275491
Sydney Lee,Ruth Ann Marrie,Giulia Fadda,Mark S Freedman,Liesly Lee,Alexandra Muccilli,Manav V Vyas,Andrea Konig,Dalia L Rotstein
{"title":"Is there a prodrome to NMOSD? An investigation of neurologic symptoms preceding the first NMOSD attack.","authors":"Sydney Lee,Ruth Ann Marrie,Giulia Fadda,Mark S Freedman,Liesly Lee,Alexandra Muccilli,Manav V Vyas,Andrea Konig,Dalia L Rotstein","doi":"10.1177/13524585241275491","DOIUrl":null,"url":null,"abstract":"BACKGROUND\r\nIt is unknown whether people with aquaporin-4 antibody positive (AQP4-IgG+) neuromyelitis optica spectrum disorder (NMOSD) experience a prodrome, although a few cases report AQP4 + serology up to 16 years before the first attack.\r\n\r\nOBJECTIVES\r\nTo evaluate whether individuals with AQP4-IgG + NMOSD have prodromal neurologic symptoms preceding the first attack.\r\n\r\nMETHODS\r\nWe reviewed medical records of participants meeting the 2015 diagnostic criteria for AQP4-IgG + NMOSD from four demyelinating disease centres in the Canadian NMOSD cohort study CANOPTICS. We searched for neurologic symptoms occurring at least 30 days before the first attack.\r\n\r\nRESULTS\r\nOf 116 participants with NMOSD, 17 (14.7%) had prodromal neurologic symptoms. The median age was 48 years (range 25-83) at first attack; 16 (94.1%) were female. Participants presented with numbness/tingling (n = 9), neuropathic pain (n = 5), visual disturbance (n = 4), tonic spasms (n = 2), Lhermitte sign (n = 2), severe headache (n = 2), incoordination (n = 2), weakness (n = 1), psychosis (n = 1) or seizure (n = 1). Of eight who underwent magnetic resonance imaging (MRI) brain, orbits and/or spinal cord, five had T2 lesions. Within 1.5-245 months (median 14) from the onset of prodromal neurologic symptoms, participants experienced their first NMOSD attack.\r\n\r\nCONCLUSIONS\r\nOne in seven people with NMOSD experienced neurologic symptoms before their first attack. Further investigation of a possible NMOSD prodrome is warranted.","PeriodicalId":18874,"journal":{"name":"Multiple Sclerosis Journal","volume":null,"pages":null},"PeriodicalIF":4.8000,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Multiple Sclerosis Journal","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/13524585241275491","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

BACKGROUND It is unknown whether people with aquaporin-4 antibody positive (AQP4-IgG+) neuromyelitis optica spectrum disorder (NMOSD) experience a prodrome, although a few cases report AQP4 + serology up to 16 years before the first attack. OBJECTIVES To evaluate whether individuals with AQP4-IgG + NMOSD have prodromal neurologic symptoms preceding the first attack. METHODS We reviewed medical records of participants meeting the 2015 diagnostic criteria for AQP4-IgG + NMOSD from four demyelinating disease centres in the Canadian NMOSD cohort study CANOPTICS. We searched for neurologic symptoms occurring at least 30 days before the first attack. RESULTS Of 116 participants with NMOSD, 17 (14.7%) had prodromal neurologic symptoms. The median age was 48 years (range 25-83) at first attack; 16 (94.1%) were female. Participants presented with numbness/tingling (n = 9), neuropathic pain (n = 5), visual disturbance (n = 4), tonic spasms (n = 2), Lhermitte sign (n = 2), severe headache (n = 2), incoordination (n = 2), weakness (n = 1), psychosis (n = 1) or seizure (n = 1). Of eight who underwent magnetic resonance imaging (MRI) brain, orbits and/or spinal cord, five had T2 lesions. Within 1.5-245 months (median 14) from the onset of prodromal neurologic symptoms, participants experienced their first NMOSD attack. CONCLUSIONS One in seven people with NMOSD experienced neurologic symptoms before their first attack. Further investigation of a possible NMOSD prodrome is warranted.
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
NMOSD 有前驱症状吗?对 NMOSD 首次发作前的神经症状进行调查。
背景目前尚不清楚水通道蛋白-4抗体阳性(AQP4-IgG+)神经脊髓炎视网膜频谱障碍(NMOSD)患者是否会出现前驱症状,尽管有少数病例报告AQP4+血清学检测结果距首次发作长达16年。目的评估 AQP4-IgG + NMOSD 患者在首次发作前是否有神经系统前驱症状。方法我们回顾了加拿大 NMOSD 队列研究 CANOPTICS 中四个脱髓鞘疾病中心符合 2015 年 AQP4-IgG + NMOSD 诊断标准的参与者的医疗记录。结果 在 116 名 NMOSD 患者中,17 人(14.7%)有前驱神经症状。首次发病时的年龄中位数为 48 岁(25-83 岁不等);16 人(94.1%)为女性。患者表现为麻木/刺痛(9 人)、神经病理性疼痛(5 人)、视觉障碍(4 人)、强直性痉挛(2 人)、Lhermitte 征(2 人)、剧烈头痛(2 人)、不协调(2 人)、虚弱(1 人)、精神病(1 人)或癫痫发作(1 人)。在接受脑部、眼眶和/或脊髓磁共振成像(MRI)检查的 8 人中,有 5 人出现 T2 病变。结论每七名 NMOSD 患者中就有一人在首次发作前出现神经症状。有必要对可能的 NMOSD 前驱症状进行进一步调查。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Multiple Sclerosis Journal
Multiple Sclerosis Journal 医学-临床神经学
CiteScore
10.90
自引率
6.90%
发文量
186
审稿时长
3-8 weeks
期刊介绍: Multiple Sclerosis Journal is a peer-reviewed international journal that focuses on all aspects of multiple sclerosis, neuromyelitis optica and other related autoimmune diseases of the central nervous system. The journal for your research in the following areas: * __Biologic basis:__ pathology, myelin biology, pathophysiology of the blood/brain barrier, axo-glial pathobiology, remyelination, virology and microbiome, immunology, proteomics * __Epidemology and genetics:__ genetics epigenetics, epidemiology * __Clinical and Neuroimaging:__ clinical neurology, biomarkers, neuroimaging and clinical outcome measures * __Therapeutics and rehabilitation:__ therapeutics, rehabilitation, psychology, neuroplasticity, neuroprotection, and systematic management Print ISSN: 1352-4585
期刊最新文献
Choroid plexus as a mediator of CNS inflammation in multiple sclerosis. Exploring the relationship between polycystic ovarian syndrome, testosterone, and multiple sclerosis in women: A nationwide cohort study and genome-wide cross-trait analysis. Impact of symptomatic multiple sclerosis therapy on pregnancy outcome. McArdle sign and neck flexion-induced change in central motor conduction in multiple sclerosis. How to avoid missing a diagnosis of neuromyelitis optica spectrum disorder.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1