S Ma, MC Morris, MJ Hubal, LM Ross, KM Huffman, CG Vann, N Moore, ER Hauser, A Bareja, R Jiang, E Kummerfeld, MD Barberio, JA Houmard, WB Bennett, JL Johnson, JA Timmons, G Broderick, VB Kraus, CF Aliferis, WE Kraus
{"title":"Sex-Specific Skeletal Muscle Gene Expression Responses to Exercise Reveal Novel Direct Mediators of Insulin Sensitivity Change","authors":"S Ma, MC Morris, MJ Hubal, LM Ross, KM Huffman, CG Vann, N Moore, ER Hauser, A Bareja, R Jiang, E Kummerfeld, MD Barberio, JA Houmard, WB Bennett, JL Johnson, JA Timmons, G Broderick, VB Kraus, CF Aliferis, WE Kraus","doi":"10.1101/2024.09.07.24313236","DOIUrl":null,"url":null,"abstract":"<strong>BACKGROUND</strong> Understanding the causal pathways, systems, and mechanisms through which exercise impacts human health is complex. This study explores molecular signaling related to whole-body insulin sensitivity (Si) by examining changes in skeletal muscle gene expression. The analysis considers differences by biological sex, exercise amount, and exercise intensity to identify potential molecular targets for developing pharmacologic agents that replicate the health benefits of exercise.","PeriodicalId":501419,"journal":{"name":"medRxiv - Endocrinology","volume":"32 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"medRxiv - Endocrinology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1101/2024.09.07.24313236","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
BACKGROUND Understanding the causal pathways, systems, and mechanisms through which exercise impacts human health is complex. This study explores molecular signaling related to whole-body insulin sensitivity (Si) by examining changes in skeletal muscle gene expression. The analysis considers differences by biological sex, exercise amount, and exercise intensity to identify potential molecular targets for developing pharmacologic agents that replicate the health benefits of exercise.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
