Yuumi AWAZUHARA, Yuki TOMONARI, Hiroko KOKOSHIMA, Yumi WAKO, Takuya DOI
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引用次数: 0
Abstract
We performed morphological and immunohistochemical analyses of erythrocyte-rich vascular proliferative lesions of mesenteric lymph nodes in six male and one female Wistar Hannover rats. These lesions are conventionally diagnosed as hemangiomas due to abundant erythrocytes. Immunostaining was positive for prospero-related homeobox 1 (Prox-1) and/or vascular endothelial growth factor receptor 3 (VEGFR3) in all lesions, suggesting a lymphangitic origin. In 6 of 7 lesions, von Willebrand factor (vWF) immunostaining was negative, suggesting a non-blood vascular origin. These results demonstrated that almost all hemangiomas in rat mesenteric lymph nodes were lymphangiomas. To the best of our knowledge, this is the first report highlighting the lymphatic origin of vascular proliferative lesions in the mesenteric lymph nodes of rats.
期刊介绍：
JTP is a scientific journal that publishes original studies in the field of toxicological pathology and in a wide variety of other related fields. The main scope of the journal is listed below.
Administrative Opinions of Policymakers and Regulatory Agencies
Adverse Events
Carcinogenesis
Data of A Predominantly Negative Nature
Drug-Induced Hematologic Toxicity
Embryological Pathology
High Throughput Pathology
Historical Data of Experimental Animals
Immunohistochemical Analysis
Molecular Pathology
Nomenclature of Lesions
Non-mammal Toxicity Study
Result or Lesion Induced by Chemicals of Which Names Hidden on Account of the Authors
Technology and Methodology Related to Toxicological Pathology
Tumor Pathology; Neoplasia and Hyperplasia
Ultrastructural Analysis
Use of Animal Models.
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