Food for thought — Paving the way for a UK roadmap towards optimum consumer safety: Development, Endorsement and Regulatory acceptance of New Approach Methodologies (NAMs) in Chemical Risk Assessment and Beyond

IF 3 4区 医学 Q1 MEDICINE, LEGAL Regulatory Toxicology and Pharmacology Pub Date : 2024-09-07 DOI:10.1016/j.yrtph.2024.105701
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Abstract

Advances in biosciences, chemistry, technology, and computer sciences have resulted in the unparalleled development of candidate New Approach Methodologies over the last few years. Many of these are potentially invaluable in the safety assessment of chemicals, but very few have been adopted for regulatory decision making. There is an immediate opportunity to use NAMs in safety assessment where the vision is to be able to predict risk more rapidly, accurately, and efficiently to further assure consumer safety.

In order to achieve this, the UK Food Standards Agency (FSA) and the Committee on Toxicity of Chemicals in Food, Consumer Products and the Environment (COT) have developed a roadmap towards acceptance and integration of these new approach methodologies into safety and risk assessments for regulatory decision making. The roadmap provides a UK blueprint for the transition of NAMs from the research laboratory to their use in regulatory decision making. This will require close collaboration across disciplines (chemists, toxicologists, informaticians, risk assessors and others), and across chemical sectors, to develop, verify and utilise appropriate models. Linking up internationally, and harmonization will be fundamental.

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启发思考--为英国实现最佳消费者安全路线图铺平道路:化学品风险评估及其他领域新方法 (NAM) 的开发、认可和监管验收。
过去几年来,生物科学、化学、技术和计算机科学的进步促使候选的 "新方法 "得到了空前的发展。其中许多方法在化学品安全评估中具有潜在的价值,但很少被监管决策所采用。目前,在安全评估中使用新方法的机会非常迫切,我们的愿景是能够更快速、准确、高效地预测风险,从而进一步确保消费者的安全。为了实现这一目标,英国食品标准局 (FSA) 和食品、消费品和环境中的化学品毒性委员会 (COT) 制定了一份路线图,旨在接受这些新方法并将其整合到安全和风险评估中,以利于监管决策。该路线图为英国提供了一个蓝图,将非吸收剂从研究实验室过渡到监管决策中使用。这将需要跨学科(化学家、毒理学家、信息学家、风险评估员等)和跨化学领域的密切合作,以开发、验证和利用适当的模型。国际间的联系和协调将是至关重要的。
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来源期刊
CiteScore
6.70
自引率
8.80%
发文量
147
审稿时长
58 days
期刊介绍: Regulatory Toxicology and Pharmacology publishes peer reviewed articles that involve the generation, evaluation, and interpretation of experimental animal and human data that are of direct importance and relevance for regulatory authorities with respect to toxicological and pharmacological regulations in society. All peer-reviewed articles that are published should be devoted to improve the protection of human health and environment. Reviews and discussions are welcomed that address legal and/or regulatory decisions with respect to risk assessment and management of toxicological and pharmacological compounds on a scientific basis. It addresses an international readership of scientists, risk assessors and managers, and other professionals active in the field of human and environmental health. Types of peer-reviewed articles published: -Original research articles of relevance for regulatory aspects covering aspects including, but not limited to: 1.Factors influencing human sensitivity 2.Exposure science related to risk assessment 3.Alternative toxicological test methods 4.Frameworks for evaluation and integration of data in regulatory evaluations 5.Harmonization across regulatory agencies 6.Read-across methods and evaluations -Contemporary Reviews on policy related Research issues -Letters to the Editor -Guest Editorials (by Invitation)
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