Bio-Nanocomposite Hydrogel Beads Based on Cellulose and Biogenic Silver Nanoparticles Prepared by ex-situ and in-situ Methods for Antibacterial Applications

IF 0.6 4区化学 Q4 CHEMISTRY, APPLIED Russian Journal of Applied Chemistry Pub Date : 2024-08-20 DOI:10.1134/s1070427224020149

Mohammed F. Silwadi, A. H. Bhat, Alathraa Mubarak Alrahbi, Hala Qassim Albattashi, Fatma Ali Albattashi, Hanan Saif Alabri

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Abstract

This study describes the fabrication and characterization of nanocomposite hydrogel beads based on Cellulose and synthesized silver nanoparticles (Ag-NPs) prepared by insitu and exsitu methods. The silver nanoparticles were synthesized by reducing silver nitrate (AgNO₃) by Sodium borohydrate (NaBH₄). Cellulose/Ag-NPs hydrogel beads were prepared using calcium chloride as the cross-linker. The hydrogel beads were characterized using FTIR and XRD. Moreover, swelling property of the cellulose /Ag-NPs hydrogel beads was investigated. The Ag release profile of the hydrogels was obtained for the amount of Ag released using Atomic Absorption spectroscopy (AAS). The cumulative release of Ag-NPs was estimated by measuring the absorbance at 405 nm of samples obtained at various time intervals. The exsitu and insitu nanocomposite hydrogels showed greater swelling behavior in comparison with virgin cellulose hydrogel. Both insitu and exsitu cellulose/Ag-NPs presented good antibacterial activities against Escherichia coli and Bacillus and with maximum zones of inhibition 12 ± 2 mm more than the pristine cellulose hydrogel thereby, have great pharmacological potential and a suitable level of safety for use in the biological systems.

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基于纤维素和生物银纳米颗粒的生物纳米复合水凝胶珠的原位和就地制备法抗菌应用

摘要本研究介绍了基于纤维素和合成银纳米粒子（Ag-NPs）的纳米复合水凝胶珠的制备和表征。银纳米粒子是用硼氢化钠（NaBH4）还原硝酸银（AgNO3）合成的。使用氯化钙作为交联剂制备了纤维素/Ag-NPs 水凝胶珠。利用傅立叶变换红外光谱和 XRD 对水凝胶珠进行了表征。此外，还研究了纤维素/Ag-NPs 水凝胶珠的溶胀特性。使用原子吸收光谱（AAS）测定了水凝胶的银释放量。通过测量不同时间间隔获得的样品在 405 纳米波长处的吸光度，估算 Ag-NPs 的累积释放量。与原生纤维素水凝胶相比，原位和原位纳米复合水凝胶表现出更大的膨胀性。原位和非原位纤维素/Ag-NPs 对大肠杆菌和芽孢杆菌都有很好的抗菌活性，最大抑菌区比原始纤维素水凝胶大 12 ± 2 mm，因此具有很大的药理潜力，在生物系统中使用也具有适当的安全性。

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来源期刊

Russian Journal of Applied Chemistry 化学-应用化学

CiteScore

1.60

自引率

11.10%

发文量

审稿时长

2-4 weeks

期刊介绍： Russian Journal of Applied Chemistry (Zhurnal prikladnoi khimii) was founded in 1928. It covers all application problems of modern chemistry, including the structure of inorganic and organic compounds, kinetics and mechanisms of chemical reactions, problems of chemical processes and apparatus, borderline problems of chemistry, and applied research.