The nutritional impact of metallic taste in head and neck cancer patients: explorations and clinical implications

IF 2.8 3区医学 Q2 HEALTH CARE SCIENCES & SERVICES Supportive Care in Cancer Pub Date : 2024-09-11 DOI:10.1007/s00520-024-08854-z

Guillaume Buiret, Hélène Brignot, Chantal Septier, Thierry Thomas-Danguin, Gilles Feron

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Abstract

Purpose

Metallic taste (MT) is frequently observed during head and neck cancer treatments, but very little is known about its impact on nutritional status. The aim of this study was to explore the impact of MT on the quality of life and nutritional status in patients with head and neck cancer expressing MT.

Methods

Questionnaires on quality of life, MT, weight, and food intake were filled out by 44 patients with head and neck cancer before, during, and up to 1 year after their treatment. Patients were divided into two groups based on their reported experience of MT.

Results

MT was commonly observed (n = 12, 27.2%), always during the treatment phase, and mostly linked with radiotherapy or radiochemotherapy. Reported MT intensity was moderate (n = 6, 40%) to high (n = 4, 26.7%). MT had a significant negative impact on quality of life linked to dysgeusia (p = 0.025). The negative impacts of MT on food intake and on weight were not significant, possibly due to a combination of sample size, dropouts, and duration of observation. Further research in this area could provide additional insights into how to better address the issue related to MT and enhance the quality of care provided to this patient population.

Conclusion

Metallic taste, experienced by 27.2% of the 44 patients with head and neck cancer, contributes to dysgeusia and results in a significant decline in quality of life associated with dysgeusia.

Trial registration

ClinicalTrials.gov trial registration number: NCT03558789.

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头颈癌患者金属味对营养的影响：探索与临床意义

目的头颈癌治疗过程中经常会出现金属味（MT），但人们对其对营养状况的影响知之甚少。本研究旨在探讨金属味对表达金属味的头颈癌患者的生活质量和营养状况的影响。方法 44 名头颈癌患者在治疗前、治疗期间和治疗后一年内填写了有关生活质量、金属味、体重和食物摄入量的调查问卷。结果MT很常见（12人，占27.2%），总是在治疗阶段出现，而且大多与放疗或放射化疗有关。报告的MT强度从中度（6人，40%）到高度（4人，26.7%）不等。口吃障碍对生活质量的负面影响很大（p = 0.025）。MT对食物摄入量和体重的负面影响并不显著，这可能是由于样本量、辍学率和观察持续时间等综合因素造成的。在这一领域的进一步研究可为如何更好地解决与MT相关的问题并提高为这一患者群体提供的护理质量提供更多的见解。结论44名头颈部癌症患者中有27.2%的人有金属味，金属味会导致味觉障碍，并导致与味觉障碍相关的生活质量显著下降。试验注册ClinicalTrials.gov试验注册号：NCT03558789。

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来源期刊

Supportive Care in Cancer 医学-康复医学

CiteScore

5.70

自引率

9.70%

发文量

751

审稿时长

3 months

期刊介绍： Supportive Care in Cancer provides members of the Multinational Association of Supportive Care in Cancer (MASCC) and all other interested individuals, groups and institutions with the most recent scientific and social information on all aspects of supportive care in cancer patients. It covers primarily medical, technical and surgical topics concerning supportive therapy and care which may supplement or substitute basic cancer treatment at all stages of the disease. Nursing, rehabilitative, psychosocial and spiritual issues of support are also included.