The effectiveness of Bio-Min toothpaste in the management of white spot lesions: a randomised control trial

IF 2 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Trials Pub Date : 2024-09-10 DOI:10.1186/s13063-024-07990-5

Ama Johal, Aoife Keogh, Honieh Bolooki

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Abstract

White spot lesions (WSL) are common side effects of orthodontic treatment with fixed appliances, in which the surface layer of enamel is demineralised. Thus, remineralisation, that is a partial or complete reversal, of these lesions can occur as they affect the surface enamel. Remineralisation with low-dose fluoride, in addition to optimal oral hygiene and diet, has been recommended to manage WSL. The aim of the planned trial is to assess the effectiveness of a fluoride-containing bioactive glass toothpaste (BioMin™) in its ability to remineralise post-orthodontic demineralised WSL. A single-centre, double-blind randomised clinical trial to assess intervention with Bio-Min toothpaste on WSL forming on the teeth of young people completing orthodontic treatment. Remineralisation of WSL can vary depending on the individual and the site of the lesion. There is a range of oral fluoride delivery methods which include toothpastes, oral rinses, and gel preparations, which can aid remineralisation of these lesions. Identifying effective methods of remineralisation to manage this common and unsightly complication of fixed appliance therapy can improve the health and aesthetics of dentition. ISRCTN.com International Standard Randomised Controlled Trials Number (ISRCTN) 14479893 . Registered on 14 May 2020

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Bio-Min牙膏治疗白斑病的效果：随机对照试验

白斑病（WSL）是使用固定矫治器进行正畸治疗的常见副作用，在这种情况下，釉质表层会脱矿。因此，当这些病变影响到表层珐琅质时，就会发生再矿化，即部分或完全逆转。除了优化口腔卫生和饮食外，还建议使用低剂量氟化物进行再矿化，以控制 WSL。计划中的试验旨在评估含氟生物活性玻璃牙膏（BioMin™）对正畸后脱矿的 WSL 再矿化能力的有效性。这是一项单中心、双盲随机临床试验，旨在评估 Bio-Min 牙膏对完成正畸治疗的年轻人牙齿上形成的 WSL 的干预效果。WSL的再矿化情况因人和病变部位而异。有一系列口服氟化物给药方法，包括牙膏、口腔漱口水和凝胶制剂，可以帮助这些病变的再矿化。确定有效的再矿化方法来处理固定矫治器治疗中常见的这种难看的并发症，可以改善牙齿的健康和美观。ISRCTN.com 国际标准随机对照试验编号 (ISRCTN) 14479893 。注册日期：2020 年 5 月 14 日

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来源期刊

Trials 医学-医学：研究与实验

CiteScore

3.80

自引率

4.00%

发文量

966

审稿时长

6 months

期刊介绍： Trials is an open access, peer-reviewed, online journal that will encompass all aspects of the performance and findings of randomized controlled trials. Trials will experiment with, and then refine, innovative approaches to improving communication about trials. We are keen to move beyond publishing traditional trial results articles (although these will be included). We believe this represents an exciting opportunity to advance the science and reporting of trials. Prior to 2006, Trials was published as Current Controlled Trials in Cardiovascular Medicine (CCTCVM). All published CCTCVM articles are available via the Trials website and citations to CCTCVM article URLs will continue to be supported.