Cholesterol-mediated functionalization of liposomes for artificial cell design

IF 14 2区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Trends in Chemistry Pub Date : 2024-09-10 DOI:10.1016/j.trechm.2024.08.003
Xin Qiao, Xiaoliang Wang, Xin Huang
{"title":"Cholesterol-mediated functionalization of liposomes for artificial cell design","authors":"Xin Qiao, Xiaoliang Wang, Xin Huang","doi":"10.1016/j.trechm.2024.08.003","DOIUrl":null,"url":null,"abstract":"<p>To achieve functionalized liposomes and their expanding applications in assembling artificial cells and solve problems of poor stability and single structure of liposomes, recent progress in state-of-the-art liposomes has employed cholesterol as an ‘anchor’ to enrich phospholipid membranes with modifications. Cholesterol is widely used because of its capacity for robust hydrophobic interactions with phospholipids. Introducing cholesterol into liposomes renders them more similar to cells. This review summarizes the various designs and applications of cholesterol-based anchors in liposomes, including surface macromolecular modification of liposomes to achieve improved properties and functionalization, cholesterol-mediated liposome membrane fusion, and cholesterol-mediated hierarchical construction of liposomes as artificial cell models. These studies guide artificial cells to reveal the behavior of life and wider applications.</p>","PeriodicalId":48544,"journal":{"name":"Trends in Chemistry","volume":null,"pages":null},"PeriodicalIF":14.0000,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Trends in Chemistry","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1016/j.trechm.2024.08.003","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0

Abstract

To achieve functionalized liposomes and their expanding applications in assembling artificial cells and solve problems of poor stability and single structure of liposomes, recent progress in state-of-the-art liposomes has employed cholesterol as an ‘anchor’ to enrich phospholipid membranes with modifications. Cholesterol is widely used because of its capacity for robust hydrophobic interactions with phospholipids. Introducing cholesterol into liposomes renders them more similar to cells. This review summarizes the various designs and applications of cholesterol-based anchors in liposomes, including surface macromolecular modification of liposomes to achieve improved properties and functionalization, cholesterol-mediated liposome membrane fusion, and cholesterol-mediated hierarchical construction of liposomes as artificial cell models. These studies guide artificial cells to reveal the behavior of life and wider applications.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
胆固醇介导的脂质体功能化用于人工细胞设计
为了实现功能化脂质体,扩大其在组装人工细胞方面的应用,并解决脂质体稳定性差和结构单一的问题,最近在最先进的脂质体方面取得的进展是采用胆固醇作为 "锚",对磷脂膜进行富集和修饰。胆固醇之所以被广泛使用,是因为它能与磷脂产生强大的疏水相互作用。将胆固醇引入脂质体可使其更接近细胞。本综述总结了脂质体中以胆固醇为基础的锚的各种设计和应用,包括脂质体表面大分子修饰以获得更好的特性和功能化、胆固醇介导的脂质体膜融合以及胆固醇介导的脂质体作为人工细胞模型的分层构建。这些研究引导人工细胞揭示生命行为,并实现更广泛的应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Trends in Chemistry
Trends in Chemistry CHEMISTRY, MULTIDISCIPLINARY-
CiteScore
28.00
自引率
0.60%
发文量
138
期刊介绍: Trends in Chemistry serves as a new global platform for discussing significant and transformative concepts across all areas of chemistry. It recognizes that breakthroughs in chemistry hold the key to addressing major global challenges. The journal offers readable, multidisciplinary articles, including reviews, opinions, and short pieces, designed to keep both students and leading scientists updated on pressing issues in the field. Covering analytical, inorganic, organic, physical, and theoretical chemistry, the journal highlights major themes such as biochemistry, catalysis, environmental chemistry, materials, medicine, polymers, and supramolecular chemistry. It also welcomes articles on chemical education, health and safety, policy and public relations, and ethics and law.
期刊最新文献
Enantiospecific 1,3-hydrogen transfer of alkenes and alkynes Subscription and Copyright Information Advisory Board and Contents Cholesterol-mediated functionalization of liposomes for artificial cell design ChemCarnival: inspiring future STEM pioneers
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1