Cholesterol-mediated functionalization of liposomes for artificial cell design

IF 14 2区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Trends in Chemistry Pub Date : 2024-09-10 DOI:10.1016/j.trechm.2024.08.003
Xin Qiao, Xiaoliang Wang, Xin Huang
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Abstract

To achieve functionalized liposomes and their expanding applications in assembling artificial cells and solve problems of poor stability and single structure of liposomes, recent progress in state-of-the-art liposomes has employed cholesterol as an ‘anchor’ to enrich phospholipid membranes with modifications. Cholesterol is widely used because of its capacity for robust hydrophobic interactions with phospholipids. Introducing cholesterol into liposomes renders them more similar to cells. This review summarizes the various designs and applications of cholesterol-based anchors in liposomes, including surface macromolecular modification of liposomes to achieve improved properties and functionalization, cholesterol-mediated liposome membrane fusion, and cholesterol-mediated hierarchical construction of liposomes as artificial cell models. These studies guide artificial cells to reveal the behavior of life and wider applications.

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胆固醇介导的脂质体功能化用于人工细胞设计
为了实现功能化脂质体,扩大其在组装人工细胞方面的应用,并解决脂质体稳定性差和结构单一的问题,最近在最先进的脂质体方面取得的进展是采用胆固醇作为 "锚",对磷脂膜进行富集和修饰。胆固醇之所以被广泛使用,是因为它能与磷脂产生强大的疏水相互作用。将胆固醇引入脂质体可使其更接近细胞。本综述总结了脂质体中以胆固醇为基础的锚的各种设计和应用,包括脂质体表面大分子修饰以获得更好的特性和功能化、胆固醇介导的脂质体膜融合以及胆固醇介导的脂质体作为人工细胞模型的分层构建。这些研究引导人工细胞揭示生命行为,并实现更广泛的应用。
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来源期刊
Trends in Chemistry
Trends in Chemistry CHEMISTRY, MULTIDISCIPLINARY-
CiteScore
28.00
自引率
0.60%
发文量
138
期刊介绍: Trends in Chemistry serves as a new global platform for discussing significant and transformative concepts across all areas of chemistry. It recognizes that breakthroughs in chemistry hold the key to addressing major global challenges. The journal offers readable, multidisciplinary articles, including reviews, opinions, and short pieces, designed to keep both students and leading scientists updated on pressing issues in the field. Covering analytical, inorganic, organic, physical, and theoretical chemistry, the journal highlights major themes such as biochemistry, catalysis, environmental chemistry, materials, medicine, polymers, and supramolecular chemistry. It also welcomes articles on chemical education, health and safety, policy and public relations, and ethics and law.
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