Prevalence and risk factors of sleep disorders in inflammatory bowel disease: a cross-sectional study

IF 2.5 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY International Journal of Colorectal Disease Pub Date : 2024-09-13 DOI:10.1007/s00384-024-04712-w
Jin-Zhi Zhang, Xiao-Zhen Song, Xiao-Na Song, Ya-Lin Shen, Hong Tang, Hong Li
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Abstract

Background

Sleep disorders are one of the major public health problems, which can potentially induce inflammation and exacerbate disease activity, resulting in compromised sleep quality. This study aimed to investigate the prevalence and risk factors associated with sleep disorders among patients with inflammatory bowel disease (IBD).

Methods

Between March 2023 and February 2024, the Pittsburgh Sleep Quality Index was employed to assess sleep quality in both IBD patients and healthy control subjects. Univariate and multivariate analysis were performed to identify the risk factors associated with SD in IBD patients.

Results

Overall, 208 IBD patients [150 Crohn’s disease (CD) and 58 ulcerative colitis (UC)] and 199 healthy individuals were included. Sleep disorders were observed in 59.6% of patients with IBD, with a higher prevalence among females (63.5%) compared to males (56.9%) (P = 0.476). The prevalence of sleep disorders in IBD patients was significantly higher than that found in healthy controls (37.7%) (all P < 0.01). The prevalence of sleep disorders among CD and UC patients was 58% and 63.8%, respectively (P = 0.291). The multivariate analysis revealed that older age (OR, 1.070; 95% CI: 1.035–1.105, P = 0.000), smoking (OR, 2.698; 95% CI: 1.089–6.685, P = 0.032), and depression (OR, 4.779; 95% CI: 1.915–11.928, P = 0.001) were risk factors for sleep disorders in IBD patients. However, higher body mass index (OR, 0.879; 95% CI: 0.790–0.977, P = 0.017) was identified as a protective factor.

Conclusion

Sleep disorders are common among IBD patients regardless of activity levels. Smoking and depression are the major risk factors.

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炎症性肠病患者睡眠障碍的患病率和风险因素:一项横断面研究
背景睡眠障碍是主要的公共卫生问题之一,它可能诱发炎症并加剧疾病活动,导致睡眠质量下降。本研究旨在调查炎症性肠病(IBD)患者中睡眠障碍的患病率和相关风险因素。方法在 2023 年 3 月至 2024 年 2 月期间,采用匹兹堡睡眠质量指数评估 IBD 患者和健康对照受试者的睡眠质量。结果共纳入 208 名 IBD 患者(150 名克罗恩病(CD)患者和 58 名溃疡性结肠炎(UC)患者)和 199 名健康人。59.6%的 IBD 患者存在睡眠障碍,其中女性(63.5%)的患病率高于男性(56.9%)(P = 0.476)。IBD患者的睡眠障碍患病率明显高于健康对照组(37.7%)(所有P均为0.01)。CD和UC患者的睡眠障碍患病率分别为58%和63.8%(P = 0.291)。多变量分析显示,年龄较大(OR,1.070;95% CI:1.035-1.105,P = 0.000)、吸烟(OR,2.698;95% CI:1.089-6.685,P = 0.032)和抑郁(OR,4.779;95% CI:1.915-11.928,P = 0.001)是 IBD 患者睡眠障碍的危险因素。结论无论活动水平如何,睡眠障碍在 IBD 患者中都很常见。吸烟和抑郁是主要的风险因素。
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来源期刊
CiteScore
4.90
自引率
3.60%
发文量
206
审稿时长
3-8 weeks
期刊介绍: The International Journal of Colorectal Disease, Clinical and Molecular Gastroenterology and Surgery aims to publish novel and state-of-the-art papers which deal with the physiology and pathophysiology of diseases involving the entire gastrointestinal tract. In addition to original research articles, the following categories will be included: reviews (usually commissioned but may also be submitted), case reports, letters to the editor, and protocols on clinical studies. The journal offers its readers an interdisciplinary forum for clinical science and molecular research related to gastrointestinal disease.
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