N-acetyl-cysteine in Intensive Care Unit Patients with Acute Respiratory Distress Syndrome due to COVID-19: A Retrospective Cohort Study.

IF 3 3区医学 Q2 CRITICAL CARE MEDICINE Journal of Intensive Care Medicine Pub Date : 2024-09-11 DOI:10.1177/08850666241281281

Diego González-Guzmán,Carlos A Andrade-Castellanos,Marco A Ponce-Gallegos,Ignacio Mesina-Estarrón,José G Mora-Almanza,Hugo E Ruelas-Moreno,Daniel Rodríguez-González,Omar Eguia-Ortega,Luis Enrique Colunga-Lozano

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Abstract

PURPOSE We assessed the potential association between N-acetyl-cysteine (NAC) and clinical outcomes in critically ill subjects with COVID-19-related ARDS. MATERIAL AND METHODS We included subjects with confirmed COVID-19 who were admitted to our ICU between March 1, 2020, and January 31, 2021, due to ARDS and necessitating invasive mechanical ventilation (IMV). Subjects who received standard of care (SOC) were compared with subjects who additionally received NAC 600 mg bid orally. RESULTS A total of 243 subjects were included in this study. The results indicate significantly improved survival rates in the NAC plus SOC group, both in the unadjusted analysis and after adjusting for confounding factors such as ARDS severity (HR 0.48, 95% CI 0.32-0.70). CONCLUSIONS We found that oral administration of NAC was associated with reduced mortality in critically ill patients with COVID-19 related ARDS.

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N-乙酰半胱氨酸在 COVID-19 引起的急性呼吸窘迫综合征重症监护室患者中的应用：回顾性队列研究

目的我们评估了 N-乙酰-半胱氨酸（NAC）与 COVID-19 相关 ARDS 重症患者临床预后之间的潜在关联。材料和方法我们纳入了 2020 年 3 月 1 日至 2021 年 1 月 31 日期间因 ARDS 而入住重症监护室并需要进行有创机械通气（IMV）的确诊 COVID-19 患者。接受标准护理（SOC）的受试者与额外口服 NAC 600 毫克的受试者进行了比较。结果表明，NAC 加 SOC 组的生存率明显提高，无论是未经调整的分析，还是调整了 ARDS 严重程度等混杂因素后的结果（HR 0.48，95% CI 0.32-0.70）。

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来源期刊

Journal of Intensive Care Medicine CRITICAL CARE MEDICINE-

CiteScore

7.60

自引率

3.20%

发文量

107

期刊介绍： Journal of Intensive Care Medicine (JIC) is a peer-reviewed bi-monthly journal offering medical and surgical clinicians in adult and pediatric intensive care state-of-the-art, broad-based analytic reviews and updates, original articles, reports of large clinical series, techniques and procedures, topic-specific electronic resources, book reviews, and editorials on all aspects of intensive/critical/coronary care.