{"title":"Exploring the Interplay Between Cannabinoids and Thymic Functions","authors":"Marvin Paulo Lins, Igor Santana De Melo","doi":"10.1093/toxsci/kfae114","DOIUrl":null,"url":null,"abstract":"Cannabinoids, derived from the Cannabis sativa plant, has garnered increasing attention for its potential therapeutic applications in various diseases. The pharmacologically active compounds in Cannabis, such as delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD), exhibit diverse immunomodulatory properties. While studies have explored the effects of cannabinoids on immune function, their specific interactions with the thymus, a primary immune organ critical for T cell development and maturation, remain an intriguing area of investigation. As the thymus plays a fundamental role in shaping the immune repertoire, understanding the interplay between cannabinoids and thymic function may shed light on potential benefits or concerns associated with Cannabis-based therapies. This article aims to provide an overview of the current scientific knowledge regarding the impact of medicinal Cannabis on the thymus and its implications for disease treatment and immune health.","PeriodicalId":23178,"journal":{"name":"Toxicological Sciences","volume":"15 1","pages":""},"PeriodicalIF":3.4000,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Toxicological Sciences","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1093/toxsci/kfae114","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"TOXICOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Cannabinoids, derived from the Cannabis sativa plant, has garnered increasing attention for its potential therapeutic applications in various diseases. The pharmacologically active compounds in Cannabis, such as delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD), exhibit diverse immunomodulatory properties. While studies have explored the effects of cannabinoids on immune function, their specific interactions with the thymus, a primary immune organ critical for T cell development and maturation, remain an intriguing area of investigation. As the thymus plays a fundamental role in shaping the immune repertoire, understanding the interplay between cannabinoids and thymic function may shed light on potential benefits or concerns associated with Cannabis-based therapies. This article aims to provide an overview of the current scientific knowledge regarding the impact of medicinal Cannabis on the thymus and its implications for disease treatment and immune health.
从大麻植物中提取的大麻素因其在各种疾病中的潜在治疗用途而日益受到关注。大麻中的药理活性化合物，如δ-9-四氢大麻酚（THC）和大麻二酚（CBD），具有多种免疫调节特性。虽然已有研究探讨了大麻素对免疫功能的影响，但它们与胸腺（对 T 细胞发育和成熟至关重要的主要免疫器官）之间的特定相互作用仍是一个引人入胜的研究领域。由于胸腺在形成免疫细胞库方面发挥着根本性作用，了解大麻素与胸腺功能之间的相互作用可能会揭示与大麻疗法相关的潜在益处或担忧。本文旨在概述目前有关药用大麻对胸腺的影响及其对疾病治疗和免疫健康的影响的科学知识。
期刊介绍：
The mission of Toxicological Sciences, the official journal of the Society of Toxicology, is to publish a broad spectrum of impactful research in the field of toxicology.
The primary focus of Toxicological Sciences is on original research articles. The journal also provides expert insight via contemporary and systematic reviews, as well as forum articles and editorial content that addresses important topics in the field.
The scope of Toxicological Sciences is focused on a broad spectrum of impactful toxicological research that will advance the multidisciplinary field of toxicology ranging from basic research to model development and application, and decision making. Submissions will include diverse technologies and approaches including, but not limited to: bioinformatics and computational biology, biochemistry, exposure science, histopathology, mass spectrometry, molecular biology, population-based sciences, tissue and cell-based systems, and whole-animal studies. Integrative approaches that combine realistic exposure scenarios with impactful analyses that move the field forward are encouraged.
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